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Ppp2r1b protein phosphatase 2 scaffold subunit A beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 315648, updated on 3-Apr-2024

Summary

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Official Symbol
Ppp2r1bprovided by RGD
Official Full Name
protein phosphatase 2 scaffold subunit A betaprovided by RGD
Primary source
RGD:1304764
See related
Ensembl:ENSRNOG00000010922 AllianceGenome:RGD:1304764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in apoptotic process involved in morphogenesis; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Predicted to be located in membrane raft. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 166.4), Spleen (RPKM 86.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60092540..60125512)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51195860..51228442)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55279278..55311768)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9, alpha-1,2-mannosyltransferase Neighboring gene uncharacterized LOC134480165 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene salt-inducible kinase 2 Neighboring gene transfer RNA proline (anticodon AGG) 89 Neighboring gene uncharacterized LOC120094336 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, et al. Cancer Lett, 2013 Jul 10. PMID 23454242, Free PMC Article
  2. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653
  3. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
  4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Names
protein phosphatase 2, regulatory subunit A, beta
NP_001020589.1
XP_017451115.3
XP_017451116.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025418.1 → NP_001020589.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

    See identical proteins and their annotated locations for NP_001020589.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098007
    UniProtKB/Swiss-Prot
    Q4QQT4
    UniProtKB/TrEMBL
    A0A8I5ZR05, A6J4G5
    Related
    ENSRNOP00000094636.1, ENSRNOT00000115714.1
    Conserved Domains (4) summary
    pfam02985
    Location:295 → 325
    HEAT; HEAT repeat
    pfam13513
    Location:191 → 240
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217 → 315
    HEAT_2; HEAT repeats
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    60092540..60125512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595626.3 → XP_017451115.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

  2. XM_017595627.3 → XP_017451116.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    UniProtKB/TrEMBL
    A0A8I6A483

RNA

  1. XR_005487815.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQT4.1 GenPept UniProtKB/Swiss-Prot:Q4QQT4

Gene LinkOut

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