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Acat1 Acetyl-CoA acetyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31695, updated on 4-Apr-2024

Summary

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Official Symbol
Acat1provided by FlyBase
Official Full Name
Acetyl-CoA acetyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0029969
Locus tag
Dmel_CG10932
See related
AllianceGenome:FB:FBgn0029969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154229_at; ACAT1; CG10932; Dmel\CG10932
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
7C1-7C1; 1-21 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7887130..7888785, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7781163..7782818, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 7f Neighboring gene Ionotropic receptor 7g Neighboring gene Nek2 Neighboring gene NADH dehydrogenase (ubiquinone) MNLL subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
  2. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article
  3. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Appocher C, et al. Hum Mol Genet, 2014 Dec 20. PMID 25096240
  4. Identifying sleep regulatory genes using a Drosophila model of insomnia. Seugnet L, et al. J Neurosci, 2009 Jun 3. PMID 19494137, Free PMC Article
  5. Direct Testing for Allele-Specific Expression Differences Between Conditions. León-Novelo L, et al. G3 (Bethesda), 2018 Feb 2. PMID 29167272, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Acetyl-CoA acetyltransferase 1
Names
Acat1-PA
Acat1-PB
CG10932-PA
CG10932-PB
NP_001284987.1
NP_572414.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7887130..7888785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298058.1 → NP_001284987.1  Acetyl-CoA acetyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3N9
    Conserved Domains (2) summary
    PLN02644
    Location:24 → 410
    PLN02644; acetyl-CoA C-acetyltransferase
    cd00751
    Location:26 → 409
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

  2. NM_132186.2 → NP_572414.1  Acetyl-CoA acetyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572414.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3N9
    Related
    FBpp0071095
    Conserved Domains (2) summary
    PLN02644
    Location:24 → 410
    PLN02644; acetyl-CoA C-acetyltransferase
    cd00751
    Location:26 → 409
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3N9 Q9W3N9

Gene LinkOut

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