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HNRNPL heterogeneous nuclear ribonucleoprotein L [ Homo sapiens (human) ]

Gene ID: 3191, updated on 7-Apr-2024

Summary

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Official Symbol
HNRNPLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
Primary source
HGNC:HGNC:5045
See related
Ensembl:ENSG00000104824 MIM:603083; AllianceGenome:HGNC:5045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPL; hnRNP-L; P/OKcl.14
Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38836370..38852347, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41640403..41656404, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39327010..39342987, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 4 Neighboring gene MPRA-validated peak3474 silencer Neighboring gene uncharacterized LOC124904712 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:39314813-39315370 Neighboring gene enoyl-CoA hydratase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39333551-39334051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39338887-39339825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39339826-39340763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39343185-39343829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10587 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39350790-39350958 Neighboring gene Sharpr-MPRA regulatory region 3140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39356343-39356918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360061-39360631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39360661-39361267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39361268-39361873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10589 Neighboring gene Ras and Rab interactor like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14603 Neighboring gene sirtuin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39384205-39384706

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis. Xu P, et al. Mol Ther, 2022 Jun 1. PMID 35278674, Free PMC Article
  2. HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer. Yu X, et al. DNA Cell Biol, 2021 Oct. PMID 34491823
  3. HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1. Zhao Y, et al. Pathol Res Pract, 2021 Feb. PMID 33418347
  4. Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer. Gu J, et al. Clin Chim Acta, 2020 Aug. PMID 32376323
  5. Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. Sun C, et al. J Virol, 2020 May 4. PMID 32161169, Free PMC Article

See all (303) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
    Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
  2. The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
    Title: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
  3. hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
    Title: hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
  4. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
    Title: FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
  5. lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
    Title: lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
  6. HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
    Title: HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
  7. HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
    Title: HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
  8. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
  9. Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
    Title: Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
  10. A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
    Title: A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35509

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA intronic binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein L
Names
epididymis secretory sperm binding protein
hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005335.2 → NP_001005335.1  heterogeneous nuclear ribonucleoprotein L isoform b

    See identical proteins and their annotated locations for NP_001005335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB044547, AC008982, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135
    Consensus CDS
    CCDS33016.1
    UniProtKB/TrEMBL
    M0QXS5
    Related
    ENSP00000470231.1, ENST00000600873.5
    Conserved Domains (1) summary
    TIGR01649
    Location:1 → 454
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  2. NM_001385651.1 → NP_001372580.1  heterogeneous nuclear ribonucleoprotein L isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a retained intron compared to variant 1. The encoded isoform (c) is longer than isoform a
    Source sequence(s)
    AC008982
    UniProtKB/TrEMBL
    A0A3B3ITJ4
    Related
    ENSP00000497920.2, ENST00000647557.2
    Conserved Domains (1) summary
    TIGR01649
    Location:100 → 624
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  3. NM_001533.3 → NP_001524.2  heterogeneous nuclear ribonucleoprotein L isoform a

    See identical proteins and their annotated locations for NP_001524.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB044547, AC008982
    Consensus CDS
    CCDS33015.1
    UniProtKB/Swiss-Prot
    A6ND69, A6NIT8, P14866, Q9H3P3
    UniProtKB/TrEMBL
    M0QXS5
    Related
    ENSP00000221419.4, ENST00000221419.10
    Conserved Domains (1) summary
    TIGR01649
    Location:100 → 587
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38836370..38852347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438739.1 → XP_047294695.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  2. XM_011526888.3 → XP_011525190.1  heterogeneous nuclear ribonucleoprotein L isoform X2

    UniProtKB/TrEMBL
    M0QXS5
    Conserved Domains (5) summary
    cd12699
    Location:322 → 395
    RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12704
    Location:438 → 521
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12780
    Location:100 → 179
    RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    TIGR01649
    Location:100 → 526
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:189 → 227
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_047438738.1 → XP_047294694.1  heterogeneous nuclear ribonucleoprotein L isoform X3

  4. XM_047438737.1 → XP_047294693.1  heterogeneous nuclear ribonucleoprotein L isoform X1

    Related
    ENSP00000469349.1, ENST00000601449.5

  5. XM_047438740.1 → XP_047294696.1  heterogeneous nuclear ribonucleoprotein L isoform X5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p14 PATCHES

    Range
    246042..262019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331966.1 → XP_054187941.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  2. XM_054331963.1 → XP_054187938.1  heterogeneous nuclear ribonucleoprotein L isoform X2

  3. XM_054331965.1 → XP_054187940.1  heterogeneous nuclear ribonucleoprotein L isoform X3

  4. XM_054331962.1 → XP_054187937.1  heterogeneous nuclear ribonucleoprotein L isoform X1

  5. XM_054331961.1 → XP_054187936.1  heterogeneous nuclear ribonucleoprotein L isoform X6

  6. XM_054331964.1 → XP_054187939.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  7. XM_054331967.1 → XP_054187942.1  heterogeneous nuclear ribonucleoprotein L isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41640403..41656404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320805.1 → XP_054176780.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  2. XM_054320802.1 → XP_054176777.1  heterogeneous nuclear ribonucleoprotein L isoform X2

  3. XM_054320804.1 → XP_054176779.1  heterogeneous nuclear ribonucleoprotein L isoform X3

  4. XM_054320801.1 → XP_054176776.1  heterogeneous nuclear ribonucleoprotein L isoform X1

  5. XM_054320800.1 → XP_054176775.1  heterogeneous nuclear ribonucleoprotein L isoform X7

  6. XM_054320803.1 → XP_054176778.1  heterogeneous nuclear ribonucleoprotein L isoform X4

  7. XM_054320806.1 → XP_054176781.1  heterogeneous nuclear ribonucleoprotein L isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14866.2 GenPept UniProtKB/Swiss-Prot:P14866

Gene LinkOut

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