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Rpl17 ribosomal protein L17 [ Mus musculus (house mouse) ]

Gene ID: 319195, updated on 3-Apr-2024

Summary

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Official Symbol
Rpl17provided by MGI
Official Full Name
ribosomal protein L17provided by MGI
Primary source
MGI:MGI:2448270
See related
Ensembl:ENSMUSG00000062328 AllianceGenome:MGI:2448270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and positive regulation of G1/S transition of mitotic cell cycle. Located in synapse. Is expressed in brain; central nervous system; embryo; pancreas epithelium; and retina. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 250.7), bladder adult (RPKM 230.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl17 in Genome Data Viewer
Location:
18 E3; 18 50.96 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75132049..75136455)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74998978..75003381)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9030625G05 gene Neighboring gene lipase, endothelial Neighboring gene STARR-positive B cell enhancer ABC_E11004 Neighboring gene STARR-positive B cell enhancer ABC_E7609 Neighboring gene STARR-positive B cell enhancer ABC_E7610 Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene predicted gene, 23301 Neighboring gene cDNA sequence BC031181 Neighboring gene predicted gene, 26202 Neighboring gene dymeclin Neighboring gene STARR-seq mESC enhancer starr_45027 Neighboring gene predicted gene, 52344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA. Wang M, et al. RNA, 2015 Jul. PMID 25995445, Free PMC Article
  2. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Smolock EM, et al. Circulation, 2012 Nov 13. PMID 23065385, Free PMC Article
  3. Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Karpova T, et al. Biol Reprod, 2015 Oct. PMID 26269506, Free PMC Article
  4. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. Salinas E, et al. J Virol, 2016 Feb 1. PMID 26581985, Free PMC Article
  5. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, et al. iScience, 2020 Apr 24. PMID 32299058, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reducing the amount of Rpl17 in mouse cells led to stalled 60S subunit maturation, causing degradation of most of the synthesized precursors
    Title: Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA.
  2. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.
    Title: Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103289, MGC118163

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables large ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL22
Names
60S ribosomal protein L17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002239.4 → NP_001002239.2  large ribosomal subunit protein uL22 isoform a

    See identical proteins and their annotated locations for NP_001002239.2

    Status: VALIDATED

    Source sequence(s)
    AC125122
    Consensus CDS
    CCDS29344.1
    UniProtKB/Swiss-Prot
    Q6ZWZ7, Q9CPR4
    UniProtKB/TrEMBL
    Q505B1
    Related
    ENSMUSP00000078654.6, ENSMUST00000079716.6
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  2. NM_001405964.1 → NP_001392893.1  large ribosomal subunit protein uL22 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125122
    UniProtKB/Swiss-Prot
    Q6ZWZ7, Q9CPR4

  3. NM_001405965.1 → NP_001392894.1  large ribosomal subunit protein uL22 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125122

  4. NM_001405966.1 → NP_001392895.1  large ribosomal subunit protein uL22 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC125122

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    75132049..75136455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525996.1 → XP_006526059.1  large ribosomal subunit protein uL22 isoform X2

    See identical proteins and their annotated locations for XP_006526059.1

    UniProtKB/Swiss-Prot
    Q6ZWZ7, Q9CPR4
    UniProtKB/TrEMBL
    Q505B1
    Related
    ENSMUSP00000157556.2, ENSMUST00000237431.2
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPR4.4 GenPept UniProtKB/Swiss-Prot:Q9CPR4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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