U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hs3st5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 319415, updated on 30-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Hs3st5provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 5provided by MGI
Primary source
MGI:MGI:2441996
See related
Ensembl:ENSMUSG00000044499 AllianceGenome:MGI:2441996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1151; Hs3ost5; D930005L05Rik
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; protein sulfation; and regulation of viral entry into host cell. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.3), whole brain E14.5 (RPKM 2.4) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 B1; 10 19.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (36382794..36710393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (36506590..36834397)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26309 Neighboring gene STARR-seq mESC enhancer starr_26310 Neighboring gene STARR-seq mESC enhancer starr_26311 Neighboring gene STARR-seq mESC enhancer starr_26312 Neighboring gene STARR-seq mESC enhancer starr_26313 Neighboring gene STARR-seq mESC enhancer starr_26314 Neighboring gene STARR-seq mESC enhancer starr_26315 Neighboring gene S-adenosylmethionine decarboxylase 2 Neighboring gene STARR-seq mESC enhancer starr_26316 Neighboring gene predicted gene, 40623 Neighboring gene STARR-seq mESC enhancer starr_26317 Neighboring gene STARR-seq mESC enhancer starr_26318 Neighboring gene STARR-seq mESC enhancer starr_26319 Neighboring gene STARR-seq mESC enhancer starr_26320 Neighboring gene STARR-seq mESC enhancer starr_26322 Neighboring gene STARR-seq mESC enhancer starr_26323 Neighboring gene STARR-seq mESC enhancer starr_26324 Neighboring gene STARR-seq mESC enhancer starr_26325 Neighboring gene VISTA enhancer mm693 Neighboring gene STARR-seq mESC enhancer starr_26326 Neighboring gene STARR-seq mESC enhancer starr_26327 Neighboring gene STARR-seq mESC enhancer starr_26330 Neighboring gene STARR-seq mESC enhancer starr_26331 Neighboring gene predicted gene, 22554 Neighboring gene STARR-seq mESC enhancer starr_26332 Neighboring gene STARR-seq mESC enhancer starr_26333 Neighboring gene STARR-seq mESC enhancer starr_26336 Neighboring gene STARR-positive B cell enhancer mm9_chr10:36693912-36694212 Neighboring gene STARR-seq mESC enhancer starr_26337 Neighboring gene STARR-seq mESC enhancer starr_26339 Neighboring gene STARR-seq mESC enhancer starr_26341 Neighboring gene STARR-seq mESC enhancer starr_26343 Neighboring gene STARR-seq mESC enhancer starr_26344 Neighboring gene STARR-positive B cell enhancer ABC_E6829 Neighboring gene histone deacetylase 2 Neighboring gene myristoylated alanine rich protein kinase C substrate

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. Chen J, et al. Glycobiology, 2003 Nov. PMID 12907690
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 5
Names
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
NP_001074677.1
NP_001240284.1
NP_001240285.1
XP_006512824.1
XP_030100975.1
XP_036011701.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081208.2 → NP_001074677.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_001074677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC079867, CJ113442
    Consensus CDS
    CCDS35881.1
    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Related
    ENSMUSP00000129434.2, ENSMUST00000168572.8
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001253355.1 → NP_001240284.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_001240284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK031910, BC079867, CJ113442
    Consensus CDS
    CCDS35881.1
    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Related
    ENSMUSP00000060229.5, ENSMUST00000058738.11
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_001253356.1 → NP_001240285.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_001240285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC079867, BC147493, CJ113442
    Consensus CDS
    CCDS35881.1
    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Related
    ENSMUSP00000130778.2, ENSMUST00000167191.8
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    36382794..36710393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512761.4 → XP_006512824.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006512824.1

    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_030245115.2 → XP_030100975.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_036155808.1 → XP_036011701.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BSL4
    UniProtKB/TrEMBL
    B2RXW6
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSL4.1 GenPept UniProtKB/Swiss-Prot:Q8BSL4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous