Idi1 isopentenyl-diphosphate delta isomerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Idi1provided by MGI
Official Full Name: isopentenyl-diphosphate delta isomeraseprovided by MGI
Primary source: MGI:MGI:2442264
See related: Ensembl:ENSMUSG00000058258 AllianceGenome:MGI:2442264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IPPI1; 4832416K17Rik
Summary: Predicted to enable isopentenyl-diphosphate delta-isomerase activity; magnesium ion binding activity; and manganese ion binding activity. Acts upstream of or within response to stilbenoid. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human IDI1 (isopentenyl-diphosphate delta isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 38.1), liver E18 (RPKM 34.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 3.62 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (8935642..8942432)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (8885606..8892396)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity
Title: Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Idi1 (e-PCR), detects polymorphism
- UniSTS:546829

Idi1 (e-PCR), detects polymorphism
- UniSTS:532554

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables isopentenyl-diphosphate delta-isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isopentenyl-diphosphate delta-isomerase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isopentenyl-diphosphate Delta-isomerase 1

Names: IPP isomerase 1; isopentenyl pyrophosphate isomerase 1

NP_663335.2

EC 5.3.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145360.2 → NP_663335.2 isopentenyl-diphosphate Delta-isomerase 1

See identical proteins and their annotated locations for NP_663335.2

Status: VALIDATED

Source sequence(s)

AC124732, AK160832, BE953932

Consensus CDS

CCDS26233.2

UniProtKB/Swiss-Prot

P58044, Q4FJU2

UniProtKB/TrEMBL

G3XA48

Related

ENSMUSP00000132780.3, ENSMUST00000169314.9

Conserved Domains (2) summary

COG1443
Location:75 → 278

Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]

cl00447
Location:77 → 283

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...