HOXA7 homeobox A7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HOXA7provided by HGNC
Official Full Name: homeobox A7provided by HGNC
Primary source: HGNC:HGNC:5108
See related: Ensembl:ENSG00000122592 MIM:142950; AllianceGenome:HGNC:5108
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANTP; HOX1; HOX1A; HOX1.1
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Expression: Broad expression in kidney (RPKM 9.4), adrenal (RPKM 7.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p15.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (27153716..27156675, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (27289707..27297085, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (27193335..27196294, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis.
Title: CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis.
MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer.
Title: MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer.
Correlation of miR-181a and three HOXA genes as useful biomarkers in acute myeloid leukemia.
Title: Correlation of miR-181a and three HOXA genes as useful biomarkers in acute myeloid leukemia.
Study found the miR-144-3p expression was reduced in neuroblastoma (NB) tissues and cell lines and resulted in the stimulation of cell proliferation, cell cycle progression, and cell migration in vitro. Homeobox protein A7 (HOXA7) was validated as a direct target of miR-144-3p. Results demonstrated the tumor suppressive role of miR-144-3p in NB.
Title: microRNA-144-3p suppresses human neuroblastoma cell proliferation by targeting HOXA7.
Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice.
Title: The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7.
data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target
Title: The expression and significance of the HOXA7 gene in oral squamous cell carcinoma.
The homeodomain and N- and C-termini are critical to transcriptional activation by Hoxa1 protein. The N-terminus also modulates interaction with Pbx1a protein during DNA-binding.
Title: Pentapeptide insertion mutagenesis of the Hoxa1 protein: mapping of transcription activation and DNA-binding regulatory domains.
HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia.
Title: All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.
HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2
Title: HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.
variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities
Title: Mutation screening of HOXA7 and HOXA9 genes in Chinese women with Müllerian duct abnormalities.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxa7 (e-PCR), detects polymorphism
- UniSTS:143372

RH48711 (e-PCR)
- UniSTS:37664

RH47950 (e-PCR)
- UniSTS:37665

ECD04160 (e-PCR)
- UniSTS:285238

Hoxa7 (e-PCR), detects polymorphism
- UniSTS:536645

NoName (e-PCR)
- UniSTS:489818

ECD10134 (e-PCR)
- UniSTS:291174

REN100569 (e-PCR)
- UniSTS:425366

REN100570 (e-PCR)
- UniSTS:425367

REN100571 (e-PCR)
- UniSTS:425368

REN100572 (e-PCR)
- UniSTS:425369

REN100573 (e-PCR)
- UniSTS:425370

REN100574 (e-PCR)
- UniSTS:425371

REN100575 (e-PCR)
- UniSTS:425372

REN100576 (e-PCR)
- UniSTS:425373

REN100577 (e-PCR)
- UniSTS:425374

REN100578 (e-PCR)
- UniSTS:425375

REN100579 (e-PCR)
- UniSTS:425376

REN100580 (e-PCR)
- UniSTS:425377

REN100581 (e-PCR)
- UniSTS:425378

ECD01169 (e-PCR)
- UniSTS:282276

REN100586 (e-PCR)
- UniSTS:425383

REN100587 (e-PCR)
- UniSTS:425384

REN100588 (e-PCR)
- UniSTS:425385

REN100589 (e-PCR)
- UniSTS:425386

ECD12537 (e-PCR)
- UniSTS:293570

ECD06385 (e-PCR)
- UniSTS:287445

ECD11282 (e-PCR)
- UniSTS:292318

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: homeobox protein Hox-A7

Names: homeo box A7; homeobox protein HOX-1A; homeobox protein Hox 1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.