smurf1 SMAD specific E3 ubiquitin protein ligase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smurf1provided by ZNC
Official Full Name: SMAD specific E3 ubiquitin protein ligase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2744
See related: Ensembl:ENSDARG00000016086 AllianceGenome:ZFIN:ZDB-GENE-040426-2744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wwp1; zgc:66401; wu:fb30b12
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of BMP signaling pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; axis; midbrain; neural plate; and notochord. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40690212..40768592, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40548354..40626753, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb30b12.x1 (e-PCR)
- UniSTS:190382

fb30b12.x1 (e-PCR)
- UniSTS:190383

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SMURF1

Names: E3 ubiquitin ligase SMURF1; WW domain containing E3 ubiquitin protein ligase 1; smad ubiquitination regulatory factor 1

NP_001001943.1

EC 2.3.2.26

XP_005164172.1

EC 2.3.2.26

XP_021325044.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001943.1 → NP_001001943.1 E3 ubiquitin-protein ligase SMURF1

See identical proteins and their annotated locations for NP_001001943.1

Status: PROVISIONAL

Source sequence(s)

BC059201

UniProtKB/TrEMBL

Q6PCR3

Related

ENSDARP00000003721.7, ENSDART00000004923.9

Conserved Domains (4) summary

cd08382
Location:14 → 138

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:234 → 266

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:397 → 728

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:373 → 728

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

40690212..40768592 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469369.1 → XP_021325044.1 E3 ubiquitin-protein ligase SMURF1 isoform X2

UniProtKB/TrEMBL

A0A8M9PJN2

Conserved Domains (3) summary

cd08382
Location:14 → 138

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:234 → 266

WW; Domain with 2 conserved Trp (W) residues

cd00078
Location:324 → 679

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_005164115.4 → XP_005164172.1 E3 ubiquitin-protein ligase SMURF1 isoform X1

UniProtKB/TrEMBL

A0A8M2BBE4

Conserved Domains (4) summary

cd08382
Location:14 → 138

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:280 → 312

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:397 → 725

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:373 → 725

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...