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pkn3 protein kinase N3 [ Danio rerio (zebrafish) ]

Gene ID: 323182, updated on 11-Apr-2024

Summary

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Official Symbol
pkn3provided by ZNC
Official Full Name
protein kinase N3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1902
See related
Ensembl:ENSDARG00000079585 AllianceGenome:ZFIN:ZDB-GENE-030131-1902
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkcl2; wu:fb92a02; si:dkey-202g15.3
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation and signal transduction. Predicted to be located in several cellular components, including cleavage furrow; midbody; and nucleus. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31828887..31857389, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31229173..31257233, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1, like 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 12b Neighboring gene iron-sulfur cluster assembly enzyme b Neighboring gene transmembrane protein 119b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kinase N3; serine/threonine-protein kinase N2
Names
protein kinase C-like 2
XP_003198687.2
XP_005172016.2
XP_021332178.1
XP_021332179.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    31828887..31857389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476503.1 → XP_021332178.1  serine/threonine-protein kinase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PYQ5, E7F7I3
    Related
    ENSDARP00000103609.3, ENSDART00000112546.4
    Conserved Domains (5) summary
    cd08687
    Location:379 → 462
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:25 → 90
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11637
    Location:199 → 271
    HR1_PKN3_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
    cd05589
    Location:614 → 938
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:111 → 183
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

  2. XM_021476504.1 → XP_021332179.1  serine/threonine-protein kinase N2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q469
    Conserved Domains (4) summary
    cd08687
    Location:264 → 347
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11637
    Location:84 → 156
    HR1_PKN3_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
    cd05589
    Location:499 → 823
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:37 → 68
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394585.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    143373..171255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003198639.5 → XP_003198687.2  serine/threonine-protein kinase N2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1RNE5
    Conserved Domains (5) summary
    cd08687
    Location:379 → 462
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:25 → 90
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11637
    Location:199 → 271
    HR1_PKN3_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
    cd05589
    Location:614 → 938
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:111 → 183
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

  2. XM_005171959.4 → XP_005172016.2  serine/threonine-protein kinase N2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BJT4
    Conserved Domains (4) summary
    cd08687
    Location:264 → 347
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11637
    Location:84 → 156
    HR1_PKN3_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N3
    cd05589
    Location:499 → 823
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:37 → 68
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
Nucleotide Protein Strain
Heading Accession and Version

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