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pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 [ Danio rerio (zebrafish) ]

Gene ID: 323588, updated on 11-Apr-2024

Summary

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Official Symbol
pik3r5provided by ZNC
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2308
See related
Ensembl:ENSDARG00000102762 AllianceGenome:ZFIN:ZDB-GENE-030131-2308
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc03h05; wu:fc03h05; si:ch73-203d16.1
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of MAP kinase activity. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pik3r5 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (19933728..19979293)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (23462433..23507888)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene syntaxin 8 Neighboring gene netrin 1a Neighboring gene uncharacterized LOC101884559 Neighboring gene uncharacterized LOC100008156

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. Encinas P, et al. PLoS One, 2013. PMID 24069208, Free PMC Article
  2. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    19933728..19979293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477349.1 → XP_021333024.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IPI8, A0A8M9Q7E2
    Related
    ENSDARP00000148730.1, ENSDART00000181632.1
    Conserved Domains (1) summary
    pfam10486
    Location:4 → 874
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394639.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    170639..222325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302367.3 → XP_009300642.2  phosphoinositide 3-kinase regulatory subunit 5 isoform X2

    UniProtKB/TrEMBL
    A0A0R4IPI8, A0A8M3BAC9
    Conserved Domains (1) summary
    pfam10486
    Location:4 → 865
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
Nucleotide Protein Strain
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