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BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens (human) ]

Gene ID: 330, updated on 3-Apr-2024

Summary

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Official Symbol
BIRC3provided by HGNC
Official Full Name
baculoviral IAP repeat containing 3provided by HGNC
Primary source
HGNC:HGNC:591
See related
Ensembl:ENSG00000023445 MIM:601721; AllianceGenome:HGNC:591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2
Summary
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Expression
Broad expression in lymph node (RPKM 48.6), appendix (RPKM 43.1) and 15 other tissues See more
Orthologs
all
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Genomic context

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See BIRC3 in Genome Data Viewer
Location:
11q22.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (102317484..102339403)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (102319603..102341520)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102188215..102210134)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902739 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:102187662-102188861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5438 Neighboring gene RNA, U6 small nuclear 952, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5440 Neighboring gene baculoviral IAP repeat containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5441 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102245101-102245686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102245687-102246271 Neighboring gene transmembrane protein 123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5442 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:102299689-102299866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exploration of induced sputum BIRC3 levels and clinical implications in asthma. Du L, et al. BMC Pulm Med, 2022 Mar 14. PMID 35287655, Free PMC Article
  2. Proteomic analysis of inhibitor of apoptosis protein‑like protein‑2 on breast cancer cell proliferation. Xiang S, et al. Mol Med Rep, 2022 Mar. PMID 35039877, Free PMC Article
  3. Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene. Kan M, et al. J Allergy Clin Immunol, 2022 Jun. PMID 34971648, Free PMC Article
  4. Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression. Quijada-Álamo M, et al. Blood Cancer J, 2021 Jul 9. PMID 34244476, Free PMC Article
  5. cIAP2 expression and clinical significance in pigmented villonodular synovitis. Ding Z, et al. J Mol Histol, 2021 Apr. PMID 33599891

See all (295) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.
    Title: CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.
  2. Identification and validation of prognostic and tumor microenvironment characteristics of necroptosis index and BIRC3 in clear cell renal cell carcinoma.
    Title: Identification and validation of prognostic and tumor microenvironment characteristics of necroptosis index and BIRC3 in clear cell renal cell carcinoma.
  3. Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population.
    Title: Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population.
  4. SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
    Title: SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
  5. [The correlation of CD49d expression pattern with molecular genetics and hotspot gene mutants in patients with chronic lymphocytic leukemia].
    Title: [The correlation of CD49d expression pattern with molecular genetics and hotspot gene mutants in patients with chronic lymphocytic leukemia].
  6. Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
    Title: Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
  7. Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.
    Title: Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.
  8. Exploration of induced sputum BIRC3 levels and clinical implications in asthma.
    Title: Exploration of induced sputum BIRC3 levels and clinical implications in asthma.
  9. Proteomic analysis of inhibitor of apoptosis proteinlike protein2 on breast cancer cell proliferation.
    Title: Proteomic analysis of inhibitor of apoptosis protein‑like protein‑2 on breast cancer cell proliferation.
  10. BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.
    Title: BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.
Submit: New GeneRIF Correction See all GeneRIFs (173)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of baculoviral IAP repeat containing 3 (BIRC3) expression as compared to untreated control PubMed
Tat tat HIV-1 Tat101 upregulates the expression of baculoviral IAP repeat-containing 3 (BIRC3; C-IAP2) in Jurkat cells PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including MIHC, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr [TRAF1 and TRAF2 downregulation] is counteracted by BIRC3 (c-IAP-2) in THP-1 cells and monocytes PubMed
vpr Anti-apoptotic proteins BIRC3 (cIAP1) and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of RIG-I signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of necroptotic process TAS
Traceable Author Statement
more info
  
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
baculoviral IAP repeat-containing protein 3
Names
IAP homolog C
RING finger protein 49
RING-type E3 ubiquitin transferase BIRC3
TNFR2-TRAF signaling complex protein
TNFR2-TRAF-signaling complex protein 1
apoptosis inhibitor 2
cellular inhibitor of apoptosis 2
inhibitor of apoptosis protein 1
mammalian IAP homolog C
NP_001156.1
NP_892007.1
XP_054224588.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065365.1 RefSeqGene

    Range
    5001..26920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1423

mRNA and Protein(s)

  1. NM_001165.5 → NP_001156.1  baculoviral IAP repeat-containing protein 3

    See identical proteins and their annotated locations for NP_001156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA805622, AA873008, AF070674, AI880555, BC037420, BE907592, BG569841, BU428906, BX415415, BX475964, U37546, U45878
    Consensus CDS
    CCDS8315.1
    UniProtKB/Swiss-Prot
    Q13489, Q16628, Q9HC27, Q9UP46
    UniProtKB/TrEMBL
    A0A669KBC7
    Related
    ENSP00000263464.4, ENST00000263464.9
    Conserved Domains (4) summary
    smart00238
    Location:254 → 322
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:441 → 530
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    pfam13920
    Location:553 → 598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21463
    Location:377 → 411
    UBA_like_SF; UBA domain-like superfamily

  2. NM_182962.3 → NP_892007.1  baculoviral IAP repeat-containing protein 3

    See identical proteins and their annotated locations for NP_892007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA805622, AA873008, AI880555, BC037420, BE907592, BG569841, BX415415, L49432, U45878
    Consensus CDS
    CCDS8315.1
    UniProtKB/Swiss-Prot
    Q13489, Q16628, Q9HC27, Q9UP46
    UniProtKB/TrEMBL
    A0A669KBC7
    Related
    ENSP00000432907.1, ENST00000532808.5
    Conserved Domains (4) summary
    smart00238
    Location:254 → 322
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:441 → 530
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    pfam13920
    Location:553 → 598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21463
    Location:377 → 411
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    102317484..102339403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    102319603..102341520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368613.1 → XP_054224588.1  baculoviral IAP repeat-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q13489, Q16628, Q9HC27, Q9UP46
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13489.2 GenPept UniProtKB/Swiss-Prot:Q13489

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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