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CG4896 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33305, updated on 4-Apr-2024

Summary

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Official Symbol
CG4896provided by FlyBase
Primary source
FLYBASE:FBgn0031319
Locus tag
Dmel_CG4896
See related
AllianceGenome:FB:FBgn0031319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4896; Dmel\CG4896
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in TARP syndrome. Orthologous to several human genes including RBM10 (RNA binding motif protein 10) and RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
21F2-21F2; 2-2 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1177690..1182454)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1177690..1182454)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene charon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-guanine transglycosylase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct measurement of pervasive weak repression by microRNAs and their role at the network level. Ma F, et al. BMC Genomics, 2018 May 15. PMID 29764374, Free PMC Article
  2. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article
  3. Striking circadian neuron diversity and cycling of Drosophila alternative splicing. Wang Q, et al. Elife, 2018 Jun 4. PMID 29863472, Free PMC Article
  4. Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza M, et al. PLoS Genet, 2015 Mar. PMID 25826266, Free PMC Article
  5. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4896-PD
CG4896-PG
CG4896-PI
CG4896-PJ
CG4896-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1177690..1182454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258901.2 → NP_001245830.2  uncharacterized protein Dmel_CG4896, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245830.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDC4
    Conserved Domains (1) summary
    cl17169
    Location:211 → 252
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_164409.4 → NP_722689.4  uncharacterized protein Dmel_CG4896, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722689.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG7, Q8IPW5, Q8IPW6
    Conserved Domains (6) summary
    smart00547
    Location:294 → 318
    ZnF_RBZ; Zinc finger domain
    cd12313
    Location:341 → 427
    RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
    cd12561
    Location:209 → 289
    RRM1_RBM5_like; RNA recognition motif 1 in RNA-binding protein 5 (RBM5) and similar proteins
    sd00029
    Location:296 → 315
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:880 → 920
    G-patch; G-patch domain
    cd16162
    Location:560 → 615
    OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins

  3. NM_001258902.2 → NP_001245831.1  uncharacterized protein Dmel_CG4896, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDC4
    Conserved Domains (1) summary
    cl17169
    Location:211 → 252
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_134739.6 → NP_608583.5  uncharacterized protein Dmel_CG4896, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608583.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GRW3, Q8IHG7
    Related
    FBpp0077633
    Conserved Domains (7) summary
    smart00547
    Location:296 → 320
    ZnF_RBZ; Zinc finger domain
    cd12313
    Location:343 → 429
    RRM1_RRM2_RBM5_like; RNA recognition motif 1 and 2 in RNA-binding protein 5 (RBM5) and similar proteins
    cd12561
    Location:211 → 291
    RRM1_RBM5_like; RNA recognition motif 1 in RNA-binding protein 5 (RBM5) and similar proteins
    sd00029
    Location:298 → 317
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:882 → 922
    G-patch; G-patch domain
    pfam08648
    Location:91 → 158
    DUF1777; Protein of unknown function (DUF1777)
    cd16162
    Location:562 → 617
    OCRE_RBM5_like; OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins

  5. NM_001272931.1 → NP_001259860.1  uncharacterized protein Dmel_CG4896, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDX7
    Conserved Domains (1) summary
    cl17169
    Location:211 → 252
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GRW3 A0A023GRW3
M9NDC4 M9NDC4
M9PDX7 M9PDX7
Q6NQZ3 Q6NQZ3
Q8IHG7 Q8IHG7
Q8IPW6 Q8IPW6

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