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Eogt EGF-domain O-GlcNAc transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33424, updated on 10-May-2024

Summary

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Official Symbol
Eogtprovided by FlyBase
Official Full Name
EGF-domain O-GlcNAc transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0264672
Locus tag
Dmel_CG9867
See related
AllianceGenome:FB:FBgn0264672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9867; Dmel\CG9867; eogt; EOGT
Summary
Enables protein N-acetylglucosaminyltransferase activity and protein O-GlcNAc transferase activity. Involved in larval chitin-based cuticle development and protein O-GlcNAcylation via threonine. Located in endoplasmic reticulum lumen. Is expressed in embryonic/larval garland cell; garland cell primordium; and organism. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
22E1-22E1; 2-6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2381097..2383073)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2381097..2383073)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44982 Neighboring gene uncharacterized protein Neighboring gene Ataxin 7 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-acetylglucosamine modification in the lumen of the endoplasmic reticulum. Ogawa M, et al. Biochim Biophys Acta, 2015 Jun. PMID 25791024
  2. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article
  3. EOGT and O-GlcNAc on secreted and membrane proteins. Varshney S, et al. Biochem Soc Trans, 2017 Apr 15. PMID 28408480, Free PMC Article
  4. Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease. Ogawa M, et al. World J Biol Chem, 2014 May 26. PMID 24921011, Free PMC Article
  5. O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Sakaidani Y, et al. Nat Commun, 2011 Dec 13. PMID 22158438

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-GlcNAcylation via threonine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-GlcNAcylation via threonine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
EGF-domain O-GlcNAc transferase
Names
CG9867-PA
CG9867-PB
EGF-domain specific O-GlcNAc transferase
Eogt-PA
Eogt-PB
NP_001259934.1
NP_608678.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2381097..2383073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134834.3 → NP_608678.1  EGF-domain O-GlcNAc transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQB7
    UniProtKB/TrEMBL
    M9PBV8
    Related
    FBpp0077447
    Conserved Domains (1) summary
    pfam04577
    Location:232 → 454
    DUF563; Protein of unknown function (DUF563)

  2. NM_001273005.1 → NP_001259934.1  EGF-domain O-GlcNAc transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQB7
    UniProtKB/TrEMBL
    M9PBV8
    Conserved Domains (1) summary
    pfam04577
    Location:232 → 454
    DUF563; Protein of unknown function (DUF563)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBV8 M9PBV8
Q9VQB7.1 Q9VQB7

Gene LinkOut

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