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Cht10 Chitinase 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355116, updated on 10-May-2024

Summary

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Official Symbol
Cht10provided by FlyBase
Official Full Name
Chitinase 10provided by FlyBase
Primary source
FLYBASE:FBgn0250907
Locus tag
Dmel_CG18140
See related
AllianceGenome:FB:FBgn0250907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LP04696; CG17682; CG18140; CG18140-PA3; Cht; cht1; Cht1; CHT1; cht10; cht3; Cht3; CHT3; DmCht1; DmCHT1; DmCht10; DmCHT10; DmCht3; DmCHT3; Dmel\CG18140
Summary
Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be active in extracellular region. Is expressed in atrium; mesothoracic segment; presumptive embryonic/larval system; and primary segmental branch primordium. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1) and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
40F7-40F7; 2-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22999574..23025915, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22892306..22918647, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene concertina Neighboring gene long non-coding RNA:CR43242 Neighboring gene Spf45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for the adaptive significance of an LTR retrotransposon sequence in a Drosophila heterochromatic gene. McCollum AM, et al. BMC Evol Biol, 2002 Mar 19. PMID 11914129, Free PMC Article
  2. Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila. de la Vega H, et al. Insect Mol Biol, 1998 Aug. PMID 9662472
  3. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
  4. Fluorescent Microscopy-Based Detection of Chitin in Intact Drosophila melanogaster. Flaven-Pouchon J, et al. Front Physiol, 2022. PMID 35557963, Free PMC Article
  5. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila.
    Title: Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitinase 10
Names
CG18140-PA
CG18140-PB
CG18140-PC
Cht10-PA
Cht10-PB
Cht10-PC
chitinase
chitinase 1
chitinase 3
chitinase-1
chitinase-3
NP_001036422.1
NP_001260697.1
NP_001260698.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22999574..23025915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042957.2 → NP_001036422.1  chitinase 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036422.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
    UniProtKB/TrEMBL
    M9PGH3
    Conserved Domains (4) summary
    cd02872
    Location:221 → 586
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:697 → 737
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1410 → 1753
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:875 → 918
    CBM_14; Chitin binding Peritrophin-A domain

  2. NM_001273769.1 → NP_001260698.1  chitinase 10, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260698.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
    UniProtKB/TrEMBL
    M9PGH3
    Conserved Domains (4) summary
    cd02872
    Location:221 → 586
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:697 → 737
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1410 → 1753
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:875 → 918
    CBM_14; Chitin binding Peritrophin-A domain

  3. NM_001273768.1 → NP_001260697.1  chitinase 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17420, O17422, Q7PL80, Q8MS85, Q9W5U2, Q9W5U3
    UniProtKB/TrEMBL
    M9PGH3
    Conserved Domains (4) summary
    cd02872
    Location:221 → 586
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:697 → 737
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1410 → 1753
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:875 → 918
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGH3 M9PGH3
Q9W5U2.2 Q9W5U2

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