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mcm4 minichromosome maintenance complex component 4 [ Danio rerio (zebrafish) ]

Gene ID: 337598, updated on 11-Apr-2024

Summary

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Official Symbol
mcm4provided by ZNC
Official Full Name
minichromosome maintenance complex component 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9544
See related
Ensembl:ENSDARG00000040041 AllianceGenome:ZFIN:ZDB-GENE-030131-9544
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb1025; fc12c09; fj85g09; zeh1616; hm:zeh1616; wu:fc12c09; wu:fj85g09
Summary
Enables chromatin binding activity. Acts upstream of or within response to yeast. Predicted to be located in chromosome. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in digestive system; nervous system; otic vesicle; pectoral fin; and proliferative region. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mcm4 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (35536662..35561672, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (35648565..35673575, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene snail family zinc finger 2 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 Neighboring gene CCAAT enhancer binding protein delta Neighboring gene scaffold protein involved in DNA repair

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Promotion effect of liver tumor progression in male kras transgenic zebrafish induced by tris (1, 3-dichloro-2-propyl) phosphate. Chen S, et al. Ecotoxicol Environ Saf, 2020 Mar 15. PMID 31991394
  2. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. Davuluri G, et al. PLoS Genet, 2008 Oct. PMID 18974873, Free PMC Article
  3. Gut-derived metabolites influence neurodevelopmental gene expression and Wnt signaling events in a germ-free zebrafish model. Rea V, et al. Microbiome, 2022 Aug 23. PMID 35996200, Free PMC Article
  4. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article
  5. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Jacob V, et al. Development, 2015 Feb 1. PMID 25564650, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM4
Names
MCM4 minichromosome maintenance deficient 4, mitotin
NP_944595.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198913.2 → NP_944595.2  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_944595.2

    Status: PROVISIONAL

    Source sequence(s)
    BC065958
    UniProtKB/TrEMBL
    A0A8M1PF67, Q6NZV2
    Related
    ENSDARP00000058563.2, ENSDART00000058564.4
    Conserved Domains (3) summary
    smart00350
    Location:249 → 752
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:147 → 269
    MCM_N; MCM N-terminal domain
    cl21455
    Location:487 → 626
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    35536662..35561672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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