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Cndp1 carnosine dipeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 338403, updated on 12-May-2024

Summary

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Official Symbol
Cndp1provided by MGI
Official Full Name
carnosine dipeptidase 1provided by MGI
Primary source
MGI:MGI:2451097
See related
Ensembl:ENSMUSG00000056162 AllianceGenome:MGI:2451097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cn1
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of cellular protein metabolic process. Located in cytosol. Is expressed in alimentary system; genitourinary system; integumental system; sensory organ; and tail. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 4.5), genital fat pad adult (RPKM 2.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E4; 18 57.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84628509..84668359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84610384..84650234, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824 Neighboring gene STARR-seq mESC enhancer starr_45248 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84524711-84525012 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84554442-84554743 Neighboring gene STARR-seq mESC enhancer starr_45250 Neighboring gene predicted gene, 31909 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene STARR-seq mESC enhancer starr_45252 Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene CNDP dipeptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Weigand T, et al. Int J Mol Sci, 2020 Jul 10. PMID 32664451, Free PMC Article
  2. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, et al. J Biol Chem, 2003 Feb 21. PMID 12473676
  3. Prenatal differentiation of mouse vomeronasal neurones. Tarozzo G, et al. Eur J Neurosci, 1998 Jan. PMID 9753148
  4. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. Veiga-da-Cunha M, et al. J Biol Chem, 2014 Jul 11. PMID 24891507, Free PMC Article
  5. Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination. Franco-Pons N, et al. Neuroscience, 2006 Jun 30. PMID 16603319

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-Ala-His dipeptidase
Names
CNDP dipeptidase 1
carnosinase 1
carnosine dipeptidase 1 (metallopeptidase M20 family)
NP_803233.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177450.4 → NP_803233.2  beta-Ala-His dipeptidase

    See identical proteins and their annotated locations for NP_803233.2

    Status: VALIDATED

    Source sequence(s)
    AK085308, AK162089, AK165706, BB499598, BY006586
    Consensus CDS
    CCDS29382.1
    UniProtKB/Swiss-Prot
    Q80XP5, Q8BUG2
    UniProtKB/TrEMBL
    A0A0R4J0V0
    Related
    ENSMUSP00000069699.8, ENSMUST00000070139.9
    Conserved Domains (2) summary
    PRK08201
    Location:16 → 479
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:13 → 480
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84628509..84668359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_386374.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUG2.1 GenPept UniProtKB/Swiss-Prot:Q8BUG2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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