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ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 338596, updated on 3-Apr-2024

Summary

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Official Symbol
ST8SIA6provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23317
See related
Ensembl:ENSG00000148488 MIM:610139; AllianceGenome:HGNC:23317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIA8F; SIAT8F; SIAT8-F; ST8SiaVI; ST8SIA-VI
Summary
This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in lung (RPKM 3.3), heart (RPKM 1.0) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
10p12.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17315421..17454595, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17333849..17473031, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17357420..17496594, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2181 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:17268719-17268933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2182 Neighboring gene Sharpr-MPRA regulatory region 14556 Neighboring gene VIM antisense RNA 1 Neighboring gene vimentin Neighboring gene MPRA-validated peak886 silencer Neighboring gene ST8SIA6 antisense RNA 1 Neighboring gene uncharacterized LOC105376436 Neighboring gene uncharacterized LOC105376437 Neighboring gene Sharpr-MPRA regulatory region 15274 Neighboring gene Sharpr-MPRA regulatory region 12998 Neighboring gene PRP38 domain containing A pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The α2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer. Hatanaka R, et al. Biochem Biophys Res Commun, 2022 Jun 11. PMID 35390672
  2. ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis. Kuai J, et al. Dig Liver Dis, 2021 Sep. PMID 33722502
  3. The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma. Qin SJ, et al. Clin Lab, 2020 Dec 1. PMID 33337846
  4. Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer. Chen Z, et al. J Gene Med, 2021 Feb. PMID 33037712
  5. Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. Yoon HK, et al. Int J Mol Sci, 2016 Aug 2. PMID 27490539, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis.
    Title: ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis.
  2. The alpha2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer.
    Title: The α2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer.
  3. ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis.
    Title: ST8SIA6-AS1 promotes the development of hepatocellular carcinoma cells through miR-338-3p/NONO Axis.
  4. Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.
    Title: Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.
  5. The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma.
    Title: The Diagnostic Value of Serum ST8SIA6-AS1 as Biomarker in Hepatocellular Carcinoma.
  6. Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
    Title: Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
  7. ST8SIA6 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia.
    Title: α-2,8-Sialyltransferase Is Involved in the Development of Multidrug Resistance via PI3K/Akt Pathway in Human Chronic Myeloid Leukemia.
  8. NK cells consistently expressed mRNA encoding ST8Sia VI, which creates alpha2,8-linked disialic acids on O-linked glycans of glycoproteins and NK cells variably expressed high levels of ST8Sia V mRNA required for GT3 expression.
    Title: Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS
Traceable Author Statement
more info
  
enables sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glycolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glycoprotein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8F
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6
sialyltransferase 8F (alpha-2, 8-sialyltransferase)
sialyltransferase St8Sia VI
NP_001004470.1
NP_001332890.1
XP_016871663.1
XP_024303745.1
XP_024303746.1
XP_047281110.1
XP_054221689.1
XP_054221690.1
XP_054221691.1
XP_054221692.1
XP_054221693.1
XP_054221694.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051597.1 RefSeqGene

    Range
    6372..145546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004470.3 → NP_001004470.1  alpha-2,8-sialyltransferase 8F isoform 1

    See identical proteins and their annotated locations for NP_001004470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL158164, AL160289, BC137103
    Consensus CDS
    CCDS31158.1
    UniProtKB/Swiss-Prot
    B0YJ97, B9EH72, P61647, Q5VZH4
    UniProtKB/TrEMBL
    Q1HAZ0
    Related
    ENSP00000366827.4, ENST00000377602.5
    Conserved Domains (1) summary
    pfam00777
    Location:138 → 391
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001345961.2 → NP_001332890.1  alpha-2,8-sialyltransferase 8F isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL158164, AL160289
    Conserved Domains (1) summary
    pfam00777
    Location:15 → 240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_144322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158164, AL160289, BC144472

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    17315421..17454595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016174.2 → XP_016871663.1  alpha-2,8-sialyltransferase 8F isoform X1

    UniProtKB/TrEMBL
    Q1HAZ0

  2. XM_024447977.2 → XP_024303745.1  alpha-2,8-sialyltransferase 8F isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:15 → 240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_024447978.2 → XP_024303746.1  alpha-2,8-sialyltransferase 8F isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:15 → 240
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_047425154.1 → XP_047281110.1  alpha-2,8-sialyltransferase 8F isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    17333849..17473031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365714.1 → XP_054221689.1  alpha-2,8-sialyltransferase 8F isoform X1

  2. XM_054365716.1 → XP_054221691.1  alpha-2,8-sialyltransferase 8F isoform X2

  3. XM_054365718.1 → XP_054221693.1  alpha-2,8-sialyltransferase 8F isoform X2

  4. XM_054365715.1 → XP_054221690.1  alpha-2,8-sialyltransferase 8F isoform X2

  5. XM_054365719.1 → XP_054221694.1  alpha-2,8-sialyltransferase 8F isoform X2

  6. XM_054365717.1 → XP_054221692.1  alpha-2,8-sialyltransferase 8F isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61647.1 GenPept UniProtKB/Swiss-Prot:P61647

Gene LinkOut

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