selenoh selenoprotein H [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenohprovided by ZNC
Official Full Name: selenoprotein Hprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030411-2
See related: Ensembl:ENSDARG00000093022 AllianceGenome:ZFIN:ZDB-GENE-030411-2
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: selh; seph; cb697; wu:fa11g07; wu:fb23d03
Summary: This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase; and in mammals, it has been shown to protect neurons against UVB-induced damage, promote mitochondrial biogenesis, and suppress cellular senescence. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (7316622..7317434)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (7297891..7298703)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development
Title: Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

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General gene information

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Markers

fc54f06.y1 (e-PCR)
- UniSTS:194063

fb23d03 (e-PCR)
- UniSTS:188978

fb23d03.x1 (e-PCR)
- UniSTS:203077

fa11g07.s1 (e-PCR)
- UniSTS:202323

aa494720 (e-PCR)
- UniSTS:186798

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: selenoprotein H

Names: etID39515.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178133.3 → NP_835234.2 selenoprotein H

Status: REVIEWED

Source sequence(s)

CT670471, EH510258

UniProtKB/TrEMBL

A0A8M1PAE4

Related

ENSDARP00000122778.1, ENSDART00000140874.2

Conserved Domains (1) summary

cl01407
Location:40 → 121

Rdx; Rdx family