chrm2a cholinergic receptor, muscarinic 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chrm2aprovided by ZNC
Official Full Name: cholinergic receptor, muscarinic 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030314-1
See related: Ensembl:ENSDARG00000098612 AllianceGenome:ZFIN:ZDB-GENE-030314-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: chrm2
Summary: Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within cardiac conduction system development and negative regulation of heart rate. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (1146040..1285188)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (1132629..1271406)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The M(2) muscarinic receptor plays a specific role in the initiation of hypoxic bradycardia in fish.
Title: Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled acetylcholine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac conduction system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: muscarinic acetylcholine receptor M2; muscarinic acetylcholine receptor M2a

Names: cholinergic receptor, muscarinic 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178301.1 → NP_840086.1 muscarinic acetylcholine receptor M2a

See identical proteins and their annotated locations for NP_840086.1

Status: PROVISIONAL

Source sequence(s)

AY039653

UniProtKB/TrEMBL

Q801M4

Related

ENSDARP00000139587.1, ENSDART00000167233.2

Conserved Domains (2) summary

pfam00001
Location:48 → 231

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:40 → 173

7tm_4; Olfactory receptor