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IGLV@ immunoglobulin lambda variable cluster [ Homo sapiens (human) ]

Gene ID: 3546, updated on 24-Mar-2019

Summary

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Gene symbol
IGLV@
Gene description
immunoglobulin lambda variable cluster
Primary source
MIM:147240
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGLV
Summary
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa (see MIM 147200) or lambda, joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig lambda light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGLC1; MIM 147220), that provides signaling functions. The lambda light chain V region is encoded by 2 types of genes: V genes and joining (J) genes (see MIM 147230). Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The lambda light chain locus on chromosome 22 contains approximately 30 functional V genes, followed by approximately 4 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]
Annotation information
not in current annotation release
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Genomic context

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Location:
22q11.2

Bibliography

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Related articles in PubMed

  1. Characterization of immunoglobulin λ light chain variable region (IGLV) gene and its relationship with clinical features in patients with POEMS syndrome. Li J, et al. Ann Hematol, 2012 Aug. PMID 22453306
  2. Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus. Queiroz RG, et al. Braz J Med Biol Res, 2001 Apr. PMID 11285465
  3. Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement. Denny CT, et al. Mol Cell Biol, 1985 Nov. PMID 3018508, Free PMC Article
  4. Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas. Zhu D, et al. Am J Hematol, 2013 May. PMID 23418012, Free PMC Article
  5. Structural repertoire of immunoglobulin λ light chains. Chailyan A, et al. Proteins, 2011 May. PMID 21365679

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that mutations in IGKV (immunoglobulin kappa variable cluster) predominate over mutations in IGLV (immunoglobulin lambda variable cluster) in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas (OAMALTL).
    Title: Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas.
  2. It was suggested that the IGLV gene influenced clinical characteristics in POEMS syndrome.
    Title: Characterization of immunoglobulin λ light chain variable region (IGLV) gene and its relationship with clinical features in patients with POEMS syndrome.
  3. An analysis of the structures of lambda chains allows the definition of a discrete set of recurring conformations of their hypervariable loops and the identification of sequence constraints that can be used to predict their structure.
    Title: Structural repertoire of immunoglobulin λ light chains.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL).
Submit: New GeneRIF Correction

General gene information

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Other Names

  • Variable region of lambda light chains
  • immunoglobulin lambda variable group
  • immunoglobulin lambda variable region gene cluster
Nucleotide Protein
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