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CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

Gene ID: 3579, updated on 11-Apr-2024

Summary

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Official Symbol
CXCR2provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 2provided by HGNC
Primary source
HGNC:HGNC:6027
See related
Ensembl:ENSG00000180871 MIM:146928; AllianceGenome:HGNC:6027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Expression
Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218125294..218137251)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218610987..218622946)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218990017..219001974)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene uncharacterized LOC124907982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218890081-218890996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218896372-218896928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899047-218899580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899581-218900113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218910221-218910722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218930441-218930983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218933725-218934588 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218940751-218941252 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219039587-219040086 Neighboring gene small nucleolar RNA U13 Neighboring gene C-X-C motif chemokine receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19. Rice CM, et al. Life Sci Alliance, 2023 Feb. PMID 36622345, Free PMC Article
  2. CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain. Qiu C, et al. J Cell Mol Med, 2022 Dec. PMID 36349481, Free PMC Article
  3. Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease. Yao Z, et al. Front Immunol, 2022. PMID 35795659, Free PMC Article
  4. Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro. Wang H, et al. J Neuroinflammation, 2022 Jun 29. PMID 35768823, Free PMC Article
  5. CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma. Yamamoto Y, et al. PLoS One, 2022. PMID 35377900, Free PMC Article

See all (402) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-kappaB signaling in diabetic kidney disease.
    Title: Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
  2. Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.
    Title: Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.
  3. Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
    Title: Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
  4. IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
    Title: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
  5. CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
    Title: CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
  6. IL8 derived from macrophages inhibits CD8[+] T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.
    Title: IL8 derived from macrophages inhibits CD8(+) T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.
  7. IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
    Title: IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
  8. Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
    Title: Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
  9. Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
    Title: Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19.
  10. CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.
    Title: CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.
Submit: New GeneRIF Correction See all GeneRIFs (295)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
WHIM syndrome 2
MedGen: C5543622 OMIM: 619407 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner PubMed
capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
matrix gag HIV-1 MA interacts with CXCR2 in primary hepatocytes PubMed
gag Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells PubMed
gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed
gag HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells PubMed
gag Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2 PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-X-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-8 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-8 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular defense response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in interleukin-8-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mast cell granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 2
Names
CXC-R2
CXCR-2
CXCR2 gene for IL8 receptor type B
GRO/MGSA receptor
IL-8 receptor type 2
IL-8R B
chemokine (CXC) receptor 2
high affinity interleukin-8 receptor B
interleukin 8 receptor type 2
interleukin 8 receptor, beta
interleukin-8 receptor type B

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052975.1 RefSeqGene

    Range
    5739..16962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168298.2 → NP_001161770.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001161770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, AJ710879, DA674925
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001557.4 → NP_001548.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124768, L19593
    Consensus CDS
    CCDS2408.1
    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4
    Related
    ENSP00000319635.2, ENST00000318507.7
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218125294..218137251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444190.1 → XP_047300146.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  2. XM_047444189.1 → XP_047300145.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  3. XM_047444187.1 → XP_047300143.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  4. XM_047444191.1 → XP_047300147.1  C-X-C chemokine receptor type 2 isoform X2

  5. XM_005246530.4 → XP_005246587.1  C-X-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_005246587.1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_047444188.1 → XP_047300144.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  7. XM_017003991.2 → XP_016859480.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4
    Conserved Domains (1) summary
    cd15178
    Location:49 → 325
    7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    218610987..218622946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341825.1 → XP_054197800.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  2. XM_054341823.1 → XP_054197798.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  3. XM_054341824.1 → XP_054197799.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  4. XM_054341821.1 → XP_054197796.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4

  5. XM_054341826.1 → XP_054197801.1  C-X-C chemokine receptor type 2 isoform X2

  6. XM_054341822.1 → XP_054197797.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P25025, Q8IUZ1, Q9P2T6, Q9P2T7
    UniProtKB/TrEMBL
    Q53PC4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25025.2 GenPept UniProtKB/Swiss-Prot:P25025

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