wnt2ba wingless-type MMTV integration site family, member 2Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt2baprovided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 2Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030717-2
See related: Ensembl:ENSDARG00000005050 AllianceGenome:ZFIN:ZDB-GENE-030717-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wnt2b
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis and sensory epithelium regeneration. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in brain; immature eye; intermediate mesoderm; pectoral fin field; and pronephros. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (48253191..48271687)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (48254631..48272928)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube
Title: Mesodermal Wnt2b signalling positively regulates liver specification.
Retinoic acid signaling from the somitic mesoderm leads to activation of wnt2b expression in the intermediate mesoderm.
Title: Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory epithelium regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Wnt-2; wingless-type MMTV integration site family, member 2Ba

Names: wingless-type MMTV integration site family, member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182876.2 → NP_878296.1 wingless-type MMTV integration site family, member 2Ba

See identical proteins and their annotated locations for NP_878296.1

Status: PROVISIONAL

Source sequence(s)

AF544026

UniProtKB/TrEMBL

Q8AY89

Related

ENSDARP00000094209.3, ENSDART00000103433.4

Conserved Domains (1) summary

pfam00110
Location:74 → 376

wnt; wnt family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

48253191..48271687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302663.3 → XP_009300938.1 protein Wnt-2 isoform X1

UniProtKB/TrEMBL

A0A8M3B3N2

Conserved Domains (1) summary

pfam00110
Location:74 → 223

wnt; wnt family