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INPP5B inositol polyphosphate-5-phosphatase B [ Homo sapiens (human) ]

Gene ID: 3633, updated on 3-Apr-2024

Summary

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Official Symbol
INPP5Bprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Bprovided by HGNC
Primary source
HGNC:HGNC:6077
See related
Ensembl:ENSG00000204084 MIM:147264; AllianceGenome:HGNC:6077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5PTase
Summary
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in lymph node (RPKM 6.6), ovary (RPKM 6.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p34.3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37860697..37947057, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37727581..37813950, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38326369..38412729, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 681 Neighboring gene chromosome 1 open reading frame 122 Neighboring gene yrdC N6-threonylcarbamoyltransferase domain containing Neighboring gene metal regulatory transcription factor 1 Neighboring gene ribosomal protein S2 pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:38330961-38332160 Neighboring gene RNA, U6 small nuclear 584, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 777 Neighboring gene uncharacterized LOC124904043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38396367-38396866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 683 Neighboring gene uncharacterized LOC105378651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38412547-38413076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38414283-38414956 Neighboring gene splicing factor 3a subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38456307-38456852 Neighboring gene RNA, U6 small nuclear 510, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling. Droubi A, et al. J Cell Biol, 2022 Sep 5. PMID 35878408, Free PMC Article
  2. Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies. Pirruccello M, et al. ACS Chem Biol, 2014 Jun 20. PMID 24742366, Free PMC Article
  3. Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. Bohdanowicz M, et al. Mol Biol Cell, 2012 Jan. PMID 22072788, Free PMC Article
  4. Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway. Williams C, et al. J Cell Sci, 2007 Nov 15. PMID 17956944
  5. Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. Speed CJ, et al. Eur J Biochem, 1995 Nov 15. PMID 8529643

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.
    Title: The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.
  2. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells
    Title: OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells.
  3. The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.
    Title: Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
  4. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl function
    Title: Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Novel association strategy with copy number variation for identifying new risk Loci of human diseases.
  6. The homologous phosphatase Inpp5b was unable to complement the Ocrl1-dependent cell migration defect.
    Title: Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase.
  7. The NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain.
    Title: A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.
  8. INPP5B is also localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC).
    Title: Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC65156, MGC71303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
type II inositol 1,4,5-trisphosphate 5-phosphatase
Names
inositol polyphosphate-5-phosphatase, 75kDa
phosphoinositide 5-phosphatase
NP_001284363.1
NP_001337156.1
NP_001337157.1
NP_001352749.1
NP_001352750.1
NP_001352751.1
NP_001352752.1
NP_001352753.1
NP_001352754.1
NP_005531.2
XP_011539694.1
XP_011539695.1
XP_016856695.2
XP_054192392.1
XP_054192393.1
XP_054192394.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297434.2 → NP_001284363.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK022846, AL929472, BC042529, BC062317, DC398675
    Consensus CDS
    CCDS72760.1
    UniProtKB/TrEMBL
    B3KMW4
    Related
    ENSP00000362118.1, ENST00000373027.5
    Conserved Domains (2) summary
    cd09093
    Location:101 → 394
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:528 → 748
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

  2. NM_001350227.2 → NP_001337156.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AK022846, AL929472, BC042529, BC062317, DC398675
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (2) summary
    cd09093
    Location:45 → 338
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:472 → 692
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

  3. NM_001350228.1 → NP_001337157.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AK022846, AL603790, AL929472, BC042529, BC062317, M74161
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (2) summary
    cd09093
    Location:45 → 338
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:472 → 692
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

  4. NM_001365820.1 → NP_001352749.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL603790, AL929472
    Consensus CDS
    CCDS41306.1
    UniProtKB/Swiss-Prot
    C9J6U5, P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1
    Conserved Domains (3) summary
    cd09093
    Location:265 → 558
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:692 → 912
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    pfam16776
    Location:6 → 150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

  5. NM_001365821.1 → NP_001352750.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    UniProtKB/Swiss-Prot
    C9J6U5, P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1
    Conserved Domains (3) summary
    cd09093
    Location:263 → 556
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:690 → 910
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    pfam16776
    Location:6 → 148
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

  6. NM_001365822.1 → NP_001352751.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (3) summary
    cd09093
    Location:243 → 536
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:670 → 890
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    cl17171
    Location:63 → 128
    PH-like; Pleckstrin homology-like domain

  7. NM_001365823.1 → NP_001352752.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform 6.
    Source sequence(s)
    AL603790, AL929472
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (3) summary
    cd09093
    Location:200 → 493
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:627 → 847
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:29 → 85
    PH-like; Pleckstrin homology-like domain

  8. NM_001365824.1 → NP_001352753.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform 6.
    Source sequence(s)
    AL603790, AL929472
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (3) summary
    cd09093
    Location:200 → 493
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:627 → 847
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:29 → 85
    PH-like; Pleckstrin homology-like domain

  9. NM_001365825.1 → NP_001352754.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472
    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (3) summary
    cd09093
    Location:146 → 439
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:573 → 793
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    cl17171
    Location:1 → 31
    PH-like; Pleckstrin homology-like domain

  10. NM_005540.3 → NP_005531.2  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 both encode the same isoform (1).
    Source sequence(s)
    AL603790, AL929472, BC042529, DA125087, M74161
    Consensus CDS
    CCDS41306.1
    UniProtKB/Swiss-Prot
    C9J6U5, P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1
    Related
    ENSP00000362115.3, ENST00000373024.8
    Conserved Domains (3) summary
    cd09093
    Location:265 → 558
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:692 → 912
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
    pfam16776
    Location:6 → 150
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

RNA

  1. NR_158628.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472

  2. NR_158629.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472

  3. NR_158630.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472

  4. NR_158631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603790, AL929472

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    37860697..37947057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541393.3 → XP_011539695.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

    See identical proteins and their annotated locations for XP_011539695.1

    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (2) summary
    cd09093
    Location:72 → 365
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:499 → 719
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

  2. XM_011541392.3 → XP_011539694.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

    See identical proteins and their annotated locations for XP_011539694.1

    UniProtKB/TrEMBL
    B3KMW4
    Conserved Domains (2) summary
    cd09093
    Location:72 → 365
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:499 → 719
    RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...

  3. XM_017001206.2 → XP_016856695.2  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

RNA

  1. XR_946643.3 RNA Sequence

  2. XR_007059978.1 RNA Sequence

  3. XR_007059977.1 RNA Sequence

  4. XR_946644.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    37727581..37813950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336419.1 → XP_054192394.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

  2. XM_054336418.1 → XP_054192393.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

  3. XM_054336417.1 → XP_054192392.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

RNA

  1. XR_008486033.1 RNA Sequence

  2. XR_008486034.1 RNA Sequence

  3. XR_008486032.1 RNA Sequence

  4. XR_008486035.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32019.4 GenPept UniProtKB/Swiss-Prot:P32019

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