arhgef1a Rho guanine nucleotide exchange factor (GEF) 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgef1aprovided by ZNC
Official Full Name: Rho guanine nucleotide exchange factor (GEF) 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030722-5
See related: Ensembl:ENSDARG00000040380 AllianceGenome:ZFIN:ZDB-GENE-030722-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb473; arhgef1; zgc:158261; si:dkey-240h12.3
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of neuron differentiation; and regulation of Rho protein signal transduction. Predicted to act upstream of or within several processes, including cell division; innate immune response; and intracellular signal transduction. Predicted to be located in Golgi apparatus and bicellular tight junction. Predicted to be active in cytoskeleton and ruffle membrane. Is expressed in several structures, including blood vessel; hindbrain neural plate; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in immunodeficiency 62 and neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to several human genes including ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (11039512..11157661, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (11121514..11188317, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 1a; rho guanine nucleotide exchange factor 2

Names: rho guanine nucleotide exchange factor (GEF) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081631.2 → NP_001075100.1 rho guanine nucleotide exchange factor 1a isoform 2

See identical proteins and their annotated locations for NP_001075100.1

Status: VALIDATED

Source sequence(s)

CT573147

UniProtKB/TrEMBL

A0A8M1NBW9, A2RUX1

Related

ENSDARP00000059101.6, ENSDART00000059102.7

Conserved Domains (4) summary

cd00029
Location:46 → 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd13393
Location:476 → 593

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

pfam00169
Location:479 → 578

PH; PH domain

pfam00621
Location:245 → 437

RhoGEF; RhoGEF domain
NM_001423384.1 → NP_001410313.1 rho guanine nucleotide exchange factor 1a isoform 1

Status: VALIDATED

Source sequence(s)

CT573147

UniProtKB/TrEMBL

A0A8M9PRC8

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

11039512..11157661 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468005.1 → XP_021323680.1 rho guanine nucleotide exchange factor 2 isoform X1

Conserved Domains (3) summary

cd00029
Location:260 → 305

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:456 → 650

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:690 → 807

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_021468006.1 → XP_021323681.1 rho guanine nucleotide exchange factor 2 isoform X2

UniProtKB/TrEMBL

A0A8M9PN51

Conserved Domains (3) summary

cd00029
Location:260 → 305

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:446 → 640

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:680 → 797

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_009294091.3 → XP_009292366.1 rho guanine nucleotide exchange factor 2 isoform X3

UniProtKB/TrEMBL

A0A8M3B3E5

Conserved Domains (3) summary

pfam00169
Location:418 → 517

PH; PH domain

pfam00621
Location:184 → 376

RhoGEF; RhoGEF domain

cl17171
Location:415 → 532

PH-like; Pleckstrin homology-like domain