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PCNA Proliferating cell nuclear antigen [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37290, updated on 4-Apr-2024

Summary

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Official Symbol
PCNAprovided by FlyBase
Official Full Name
Proliferating cell nuclear antigenprovided by FlyBase
Primary source
FLYBASE:FBgn0005655
Locus tag
Dmel_CG9193
See related
AllianceGenome:FB:FBgn0005655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
53/13; CG9193; Dmel\CG9193; DmPCNA; DmPCNA1; dPCNA; l(2)02448; l(2)56F; l(2)56Fa; l(2)s1534; mus 209; mus209; Mus209; MUS209; pcna; Pcna; PCNA/mus209; PCNA1
Summary
Enables chromatin binding activity. Involved in several processes, including mitotic spindle organization; response to hydrogen peroxide; and response to methyl methanesulfonate. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including embryonic brain; extended germ band embryo; gonad; gut; and pronucleus. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
56F11-56F11; 2-90 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20261754..20262883, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16149259..16150388, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Arginyltransferase 1 Neighboring gene Hormone-sensitive lipase Neighboring gene plutonium Neighboring gene Ribosomal protein S18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Superresolution imaging of chromatin fibers to visualize epigenetic information on replicative DNA. Wooten M, et al. Nat Protoc, 2020 Mar. PMID 32051613, Free PMC Article
  2. Illuminating DNA replication during Drosophila development using TALE-lights. Yuan K, et al. Curr Biol, 2014 Feb 17. PMID 24556431, Free PMC Article
  3. Structure of PCNA from Drosophila melanogaster. Wang K, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Apr 1. PMID 23545643, Free PMC Article
  4. Germline genomic instability in PCNA mutants of Drosophila: DNA fingerprinting and microsatellite analysis. López A, et al. Mutat Res, 2005 Mar 1. PMID 15708584
  5. Site-specific mutagenesis of Drosophila proliferating cell nuclear antigen enhances its effects on calf thymus DNA polymerase delta. Mozzherin DJ, et al. BMC Biochem, 2004 Aug 13. PMID 15310391, Free PMC Article

See all (330) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
    Title: Control of e2f1 and PCNA by Drosophila transcription factor DREF.
  2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
    Title: Structure of PCNA from Drosophila melanogaster.
  3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
    Title: Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.
  4. E2F regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
    Title: The contribution of E2F-regulated transcription to Drosophila PCNA gene function.
  5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta. Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
    Title: Site-specific mutagenesis of Drosophila proliferating cell nuclear antigen enhances its effects on calf thymus DNA polymerase delta.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA polymerase processivity factor activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA-templated DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in eggshell chorion gene amplification TAS
Traceable Author Statement
more info
 PubMed 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to methyl methanesulfonate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proliferating cell nuclear antigen
Names
CG9193-PA
CG9193-PB
PCNA-PA
PCNA-PB
Proliferating-cell-nuclear-antigen
mutagen-sensitive 209
proliferating-cell nuclear antigen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20261754..20262883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057557.4 → NP_476905.1  proliferating cell nuclear antigen, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476905.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17917, Q540V1, Q9V909
    Related
    FBpp0085619
    Conserved Domains (1) summary
    TIGR00590
    Location:1 → 259
    pcna; proliferating cell nuclear antigen (pcna)

  2. NM_206182.2 → NP_995904.1  proliferating cell nuclear antigen, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995904.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17917, Q540V1, Q9V909
    Conserved Domains (1) summary
    TIGR00590
    Location:1 → 259
    pcna; proliferating cell nuclear antigen (pcna)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17917.2 P17917
Q868I9 Q868I9

Gene LinkOut

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