CD82 CD82 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD82provided by HGNC
Official Full Name: CD82 moleculeprovided by HGNC
Primary source: HGNC:HGNC:6210
See related: Ensembl:ENSG00000085117 MIM:600623; AllianceGenome:HGNC:6210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
Summary: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p11.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (44564409..44620358)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (44720425..44776379)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (44587213..44641908)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
Title: CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
Title: Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
Title: Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
Title: Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
Title: Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
Title: Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
A positive COX-2/IL-1beta loop promotes decidualization by upregulating CD82.
Title: A positive COX-2/IL-1β loop promotes decidualization by upregulating CD82.
The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
Title: The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
CD82 is a marker to isolate beta cell precursors from human iPS cells and plays a role for the maturation of beta cells.
Title: CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells.
Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1.
Title: Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1.

Submit: New GeneRIF Correction See all GeneRIFs (173)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD82	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection	PubMed
Envelope surface glycoprotein gp160, precursor	env	Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection	PubMed
	env	CD82 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles	PubMed
	env	DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures	PubMed
Pr55(Gag)	gag	HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains	PubMed
	gag	DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures	PubMed
Vpu	vpu	HIV-1 Vpu is the main determinant for the overall downregulation of CD82 in HIV-1-infected CD4+ T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-X53795 (e-PCR)
- UniSTS:29980

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

sY3084 (e-PCR)
- UniSTS:515126

STS-X53795 (e-PCR)
- UniSTS:31570

D11S3114 (e-PCR)
- UniSTS:152207

D16S325 (e-PCR)
- UniSTS:147089

G02140 (e-PCR)
- UniSTS:10937

SHGC-146608 (e-PCR)
- UniSTS:175324

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CD82 antigen

Names: C33 antigen; inducible membrane protein R2; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); metastasis suppressor Kangai-1; tetraspanin-27; tspan-27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023234.1 RefSeqGene

Range

5073..59768

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024844.2 → NP_001020015.1 CD82 antigen isoform 2

See identical proteins and their annotated locations for NP_001020015.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks a segment in the middle region, as compared to isoform 1.

Source sequence(s)

AC010768, AY303776, CB127804, U20770

Consensus CDS

CCDS31469.1

UniProtKB/TrEMBL

Q6LET0

Related

ENSP00000339686.3, ENST00000342935.7

Conserved Domains (2) summary

cd03160
Location:86 → 204

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:24 → 231

Tetraspannin; Tetraspanin family
NM_002231.4 → NP_002222.1 CD82 antigen isoform 1

See identical proteins and their annotated locations for NP_002222.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC010768, CB127804, U20770

Consensus CDS

CCDS7909.1

UniProtKB/Swiss-Prot

D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

UniProtKB/TrEMBL

Q6LET0

Related

ENSP00000227155.4, ENST00000227155.9

Conserved Domains (2) summary

cd03160
Location:106 → 229

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:24 → 256

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

44564409..44620358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426900.1 → XP_047282856.1 CD82 antigen isoform X1
XM_047426901.1 → XP_047282857.1 CD82 antigen isoform X2
XM_047426903.1 → XP_047282859.1 CD82 antigen isoform X3

UniProtKB/Swiss-Prot

D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2
XM_047426904.1 → XP_047282860.1 CD82 antigen isoform X3

UniProtKB/Swiss-Prot

D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2
XM_011520067.3 → XP_011518369.1 CD82 antigen isoform X4

UniProtKB/TrEMBL

Q6LET0

Conserved Domains (2) summary

cd03160
Location:75 → 198

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:23 → 225

Tetraspannin; Tetraspanin family