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SPTAN1 spectrin alpha, non-erythrocytic 1 [ Gallus gallus (chicken) ]

Gene ID: 374234, updated on 3-Apr-2024

Summary

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Symbol
SPTAN1provided by CGNC
Full Name
spectrin alpha, non-erythrocytic 1provided by CGNC
Primary source
CGNC:3498
See related
Ensembl:ENSGALG00010028556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SPECA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
62
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (5815166..5861030)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (5229136..5275008)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene GLE1, RNA export mediator Neighboring gene uncharacterized LOC107052167 Neighboring gene WD repeat domain 34 Neighboring gene uncharacterized LOC112529986 Neighboring gene SET nuclear proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein Motional Details Revealed by Complementary Structural Biology Techniques. Grohe K, et al. Structure, 2020 Sep 1. PMID 32579946
  2. Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins. Grohe K, et al. J Biomol NMR, 2017 May. PMID 28393279
  3. Thermal stability of chicken brain α-spectrin repeat 17: a spectroscopic study. Brenner AK, et al. J Biomol NMR, 2012 Jun. PMID 22569754
  4. Different members of a simple three-helix bundle protein family have very different folding rate constants and fold by different mechanisms. Wensley BG, et al. J Mol Biol, 2009 Jul 31. PMID 19445951, Free PMC Article
  5. The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: understanding the determinants of binding affinity by comparison with Abl-SH3. Casares S, et al. BMC Struct Biol, 2007 Apr 2. PMID 17407569, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Motional Details Revealed by Complementary Structural Biology Techniques.
    Title: Protein Motional Details Revealed by Complementary Structural Biology Techniques.
  2. Tracking of the NMR HN peak intensities for 2 weeks reports on site-specific hydrogen bond strength and also likely reflects water accessibility in a qualitative manner.
    Title: Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins.
  3. Spectroscopic study of the thermal stability of chicken brain alpha-spectrin repeat 17.
    Title: Thermal stability of chicken brain α-spectrin repeat 17: a spectroscopic study.
  4. The rate-limiting transition state for R15 folding is investigated using protein engineering methods (Phi-value analysis) and compared with previously completed analyses of R16 and R17 (15th, 16th repeats of alpha-spectrin).
    Title: Different members of a simple three-helix bundle protein family have very different folding rate constants and fold by different mechanisms.
  5. Spectrin-titin domain pairs of both spectrin R16 and R17 with a single titin I27 domain at either the N- or the C-terminus were created and found that spectrin domains are significantly stabilized, by nonnative interactions at the C-terminus only.
    Title: Distinguishing specific and nonspecific interdomain interactions in multidomain proteins.
  6. protein engineering phi-value analysis of the 16th domain of brain alpha-spectrin
    Title: The folding of spectrin domains II: phi-value analysis of R16.
  7. kinetic characterisation of the wild-type forms of the 15th, 16th, and 17th domains of brain alpha-spectrin
    Title: The folding of spectrin domains I: wild-type domains have the same stability but very different kinetic properties.
  8. Data show that mutation of alpha-spectrin asparagine 47 to alanine induces the formation of amyloid fibrils under mild acid conditions.
    Title: A single mutation induces amyloid aggregation in the alpha-spectrin SH3 domain: analysis of the early stages of fibril formation.
  9. The high-resolution structure of the complex between the R21A mutant of Spc-SH3 and p41 derived from nuclear magnetic resonance data, is presented.
    Title: The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: understanding the determinants of binding affinity by comparison with Abl-SH3.
  10. Results describe the folding pathway of the 17th domain of chicken brain alpha-spectrin, R17.
    Title: The folding pathway of spectrin R17 from experiment and simulation: using experimentally validated MD simulations to characterize States hinted at by experiment.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
spectrin alpha chain, non-erythrocytic 1
Names
alpha-II spectrin
alpha-spectrin
fodrin alpha chain
nonerythroid alpha-spectrin
spectrin alpha chain, brain
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
spectrin, non-erythroid alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042538.2 → NP_001036003.2  spectrin alpha chain, non-erythrocytic 1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    A0A8V1AEP9
    Related
    ENSGALP00010042613.1, ENSGALT00010069171.1
    Conserved Domains (4) summary
    smart00150
    Location:49 → 145
    SPEC; Spectrin repeats
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2332 → 2400
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5815166..5861030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901619.1 → XP_046757575.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  2. XM_046901623.1 → XP_046757579.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    Related
    ENSGALP00010042618.1, ENSGALT00010069176.1

  3. XM_046901627.1 → XP_046757583.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  4. XM_046901621.1 → XP_046757577.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  5. XM_046901634.1 → XP_046757590.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  6. XM_046901624.1 → XP_046757580.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  7. XM_046901629.1 → XP_046757585.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  8. XM_046901622.1 → XP_046757578.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  9. XM_046901633.1 → XP_046757589.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  10. XM_046901625.1 → XP_046757581.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  11. XM_046901631.1 → XP_046757587.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  12. XM_046901632.1 → XP_046757588.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  13. XM_046901626.1 → XP_046757582.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  14. XM_046901628.1 → XP_046757584.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  15. XM_046901620.1 → XP_046757576.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  16. XM_046901630.1 → XP_046757586.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  17. XM_040648916.2 → XP_040504850.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V1AH25
    Related
    ENSGALP00010042615.1, ENSGALT00010069173.1
    Conserved Domains (5) summary
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1675 → 1779
    Spectrin; Spectrin repeat
    pfam08726
    Location:2440 → 2508
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  18. XM_015279289.4 → XP_015134775.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V1AH25
    Conserved Domains (5) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1663 → 1767
    Spectrin; Spectrin repeat
    pfam08726
    Location:2428 → 2496
    EFhand_Ca_insen; Ca2+ insensitive EF hand

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5229136..5275008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928669.1 → XP_046784625.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  2. XM_046928674.1 → XP_046784630.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  3. XM_046928679.1 → XP_046784635.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  4. XM_046928671.1 → XP_046784627.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  5. XM_046928686.1 → XP_046784642.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  6. XM_046928675.1 → XP_046784631.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  7. XM_046928681.1 → XP_046784637.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  8. XM_046928672.1 → XP_046784628.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  9. XM_046928685.1 → XP_046784641.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  10. XM_046928676.1 → XP_046784632.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  11. XM_046928683.1 → XP_046784639.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  12. XM_046928684.1 → XP_046784640.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  13. XM_046928677.1 → XP_046784633.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  14. XM_046928680.1 → XP_046784636.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  15. XM_046928670.1 → XP_046784626.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

  16. XM_046928682.1 → XP_046784638.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

  17. XM_046928673.1 → XP_046784629.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

  18. XM_046928678.1 → XP_046784634.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07751.3 GenPept UniProtKB/Swiss-Prot:P07751

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