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MAST4 microtubule associated serine/threonine kinase family member 4 [ Homo sapiens (human) ]

Gene ID: 375449, updated on 5-Mar-2024

Summary

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Official Symbol
MAST4provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase family member 4provided by HGNC
Primary source
HGNC:HGNC:19037
See related
Ensembl:ENSG00000069020 MIM:618002; AllianceGenome:HGNC:19037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in esophagus (RPKM 3.2), fat (RPKM 2.7) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See MAST4 in Genome Data Viewer
Location:
5q12.3
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (66596393..67169593)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (67418473..67991744)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65892221..66465421)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379002 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:65806587-65807786 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:65813935-65815134 Neighboring gene long intergenic non-protein coding RNA 2229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22621 Neighboring gene peptidylprolyl isomerase A pseudogene 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22622 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66075742-66076941 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66125559-66126060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16068 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66137580-66138081 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66145039-66146238 Neighboring gene Sharpr-MPRA regulatory region 1390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66199778-66200630 Neighboring gene Sharpr-MPRA regulatory region 14441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16069 Neighboring gene Sharpr-MPRA regulatory region 14150 Neighboring gene MAST4 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66354795-66355337 Neighboring gene Sharpr-MPRA regulatory region 2367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:66462629-66463134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22624 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:66501978-66503177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22625 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:66515108-66515295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22626 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66528881-66529430 Neighboring gene CD180 molecule Neighboring gene TCL1A interacting lncRNA, retroperitoneal liposarcoma associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease. Cui Y, et al. J Bone Miner Res, 2022 Apr. PMID 35064934
  2. Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway. Lee SJ, et al. Cell Death Differ, 2021 May. PMID 33219327, Free PMC Article
  3. [Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family]. Sun L, et al. Mol Biol (Mosk), 2006 Sep-Oct. PMID 17086981
  4. Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes. Landoulsi Z, et al. Neurogenetics, 2018 Aug. PMID 29948376
  5. A genome-wide association study of carotid atherosclerosis in HIV-infected men. Shrestha S, et al. AIDS, 2010 Feb 20. PMID 20009918, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
    Title: Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
  2. Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
    Title: Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
  3. Molecular studies incriminated different genes, mainly CACNA1H and MAST4. Since at least 2 susceptibility genes were likely shared by different populations, genetic factors involved in the majority of Tunisian Genetic generalized epilepsies families remain to be discovered.
    Title: Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes.
  4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
    Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. high expression level of MAST4 in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
    Title: [Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
EBI GWAS Catalog
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16540, FLJ33039, KIAA0303, DKFZp686N1467, DKFZp686E18148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated serine/threonine-protein kinase 4
NP_001158136.1
NP_001277155.1
NP_001277156.1
NP_001277157.1
NP_001284580.1
NP_001380453.1
NP_001380454.1
NP_001380455.1
NP_001380456.1
NP_001380457.1
NP_055998.1
NP_942123.1
XP_006714669.1
XP_011541686.1
XP_011541687.1
XP_011541688.1
XP_016864938.1
XP_016864939.1
XP_016864941.1
XP_016864942.1
XP_024301812.1
XP_047273113.1
XP_047273114.1
XP_047273115.1
XP_047273116.1
XP_047273117.1
XP_047273118.1
XP_047273119.1
XP_047273120.1
XP_047273121.1
XP_054208513.1
XP_054208514.1
XP_054208515.1
XP_054208516.1
XP_054208517.1
XP_054208518.1
XP_054208519.1
XP_054208520.1
XP_054208521.1
XP_054208522.1
XP_054208523.1
XP_054208524.1
XP_054208525.1
XP_054208526.1
XP_054208527.1
XP_054208528.1
XP_054208529.1
XP_054208530.1
XP_054208531.1
XP_054208532.1
XP_054208533.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034036.1 RefSeqGene

    Range
    5046..578246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164664.2 → NP_001158136.1  microtubule-associated serine/threonine-protein kinase 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799, AC092373
    Consensus CDS
    CCDS54861.1
    UniProtKB/Swiss-Prot
    A6NL49, B5ME48, E7EWQ5, J3QT34, O15021, Q05EE6, Q6ZN07, Q8N4X4, Q96LY3
    Related
    ENSP00000385727.1, ENST00000403625.7
    Conserved Domains (4) summary
    cd00992
    Location:1146 → 1224
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:569 → 848
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:258 → 531
    DUF1908; Domain of unknown function (DUF1908)
    cl26464
    Location:1811 → 2189
    Atrophin-1; Atrophin-1 family

  2. NM_001290226.2 → NP_001277155.1  microtubule-associated serine/threonine-protein kinase 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB002301, AC044799, AK299538
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    B4DS23
    Conserved Domains (4) summary
    smart00220
    Location:364 → 637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:940 → 1018
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:363 → 642
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49 → 325
    DUF1908; Domain of unknown function (DUF1908)

  3. NM_001290227.2 → NP_001277156.1  microtubule-associated serine/threonine-protein kinase 4 isoform 5

    See identical proteins and their annotated locations for NP_001277156.1

    Status: REVIEWED

    Source sequence(s)
    AC044799, AK296707
    UniProtKB/TrEMBL
    B4DKT8
    Conserved Domains (4) summary
    PHA03247
    Location:1550 → 1928
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:885 → 963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  4. NM_001290228.2 → NP_001277157.1  microtubule-associated serine/threonine-protein kinase 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC092373, AY439222, BC033215, CB044105
    Consensus CDS
    CCDS78015.1
    UniProtKB/TrEMBL
    E7EX28, Q6T2V4
    Related
    ENSP00000384547.1, ENST00000406039.5

  5. NM_001297651.2 → NP_001284580.1  microtubule-associated serine/threonine-protein kinase 4 isoform 7

    See identical proteins and their annotated locations for NP_001284580.1

    Status: REVIEWED

    Source sequence(s)
    AC044799, AK057601, AK299706, AY830839, BF515864
    Consensus CDS
    CCDS75254.1
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    B4DSE5
    Related
    ENSP00000261569.7, ENST00000261569.11
    Conserved Domains (4) summary
    smart00220
    Location:376 → 649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:952 → 1030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  6. NM_001393524.1 → NP_001380453.1  microtubule-associated serine/threonine-protein kinase 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799, AC092373
    Conserved Domains (3) summary
    PHA03247
    Location:1814 → 2192
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:1149 → 1227
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:572 → 851
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

  7. NM_001393525.1 → NP_001380454.1  microtubule-associated serine/threonine-protein kinase 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799, AC092373
    Conserved Domains (3) summary
    PHA03247
    Location:1744 → 2122
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:1079 → 1157
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:569 → 848
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

  8. NM_001393526.1 → NP_001380455.1  microtubule-associated serine/threonine-protein kinase 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799
    Conserved Domains (3) summary
    PHA03247
    Location:1555 → 1933
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:890 → 968
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:380 → 659
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

  9. NM_001393527.1 → NP_001380456.1  microtubule-associated serine/threonine-protein kinase 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC044799
    Conserved Domains (4) summary
    PHA03247
    Location:1550 → 1928
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:885 → 963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  10. NM_001393528.1 → NP_001380457.1  microtubule-associated serine/threonine-protein kinase 4 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799
    Conserved Domains (4) summary
    PHA03247
    Location:1543 → 1921
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:878 → 956
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368 → 647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57 → 330
    DUF1908; Domain of unknown function (DUF1908)

  11. NM_015183.3 → NP_055998.1  microtubule-associated serine/threonine-protein kinase 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC016634, AC044799, AY830839
    Consensus CDS
    CCDS47225.1
    UniProtKB/Swiss-Prot
    O15021
    Related
    ENSP00000384313.1, ENST00000403666.5
    Conserved Domains (4) summary
    smart00220
    Location:381 → 654
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:957 → 1035
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:380 → 659
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:69 → 342
    DUF1908; Domain of unknown function (DUF1908)

  12. NM_198828.3 → NP_942123.1  microtubule-associated serine/threonine-protein kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_942123.1

    Status: REVIEWED

    Source sequence(s)
    BC033215
    Consensus CDS
    CCDS47224.1
    UniProtKB/TrEMBL
    Q6T2V4
    Related
    ENSP00000385088.1, ENST00000406374.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    66596393..67169593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446044.2 → XP_024301812.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:1218 → 1296
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:641 → 920
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:330 → 603
    DUF1908; Domain of unknown function (DUF1908)
    cl26464
    Location:1883 → 2261
    Atrophin-1; Atrophin-1 family

  2. XM_047417157.1 → XP_047273113.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

  3. XM_047417158.1 → XP_047273114.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

  4. XM_047417159.1 → XP_047273115.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

  5. XM_047417160.1 → XP_047273116.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

  6. XM_017009452.2 → XP_016864941.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  7. XM_017009450.2 → XP_016864939.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

  8. XM_047417164.1 → XP_047273120.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  9. XM_017009449.2 → XP_016864938.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

    Related
    ENSP00000384099.1, ENST00000405643.5

  10. XM_047417161.1 → XP_047273117.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

  11. XM_011543385.4 → XP_011541687.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

    Conserved Domains (4) summary
    smart00220
    Location:361 → 634
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:937 → 1015
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:360 → 639
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49 → 322
    DUF1908; Domain of unknown function (DUF1908)

  12. XM_047417163.1 → XP_047273119.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

  13. XM_006714606.4 → XP_006714669.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

    See identical proteins and their annotated locations for XP_006714669.1

    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    smart00220
    Location:376 → 649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:952 → 1030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375 → 654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64 → 337
    DUF1908; Domain of unknown function (DUF1908)

  14. XM_047417165.1 → XP_047273121.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  15. XM_017009453.2 → XP_016864942.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  16. XM_011543386.3 → XP_011541688.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

    Conserved Domains (4) summary
    smart00220
    Location:358 → 631
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:934 → 1012
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:357 → 636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:46 → 319
    DUF1908; Domain of unknown function (DUF1908)

  17. XM_011543384.3 → XP_011541686.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

    Conserved Domains (4) summary
    smart00220
    Location:370 → 643
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:946 → 1024
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:369 → 648
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:58 → 331
    DUF1908; Domain of unknown function (DUF1908)

  18. XM_047417162.1 → XP_047273118.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    67418473..67991744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352538.1 → XP_054208513.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

  2. XM_054352539.1 → XP_054208514.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

  3. XM_054352540.1 → XP_054208515.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

  4. XM_054352541.1 → XP_054208516.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

  5. XM_054352542.1 → XP_054208517.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

  6. XM_054352547.1 → XP_054208522.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

  7. XM_054352543.1 → XP_054208518.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

  8. XM_054352550.1 → XP_054208525.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

  9. XM_054352548.1 → XP_054208523.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

  10. XM_054352556.1 → XP_054208531.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

  11. XM_054352551.1 → XP_054208526.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

  12. XM_054352553.1 → XP_054208528.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

  13. XM_054352552.1 → XP_054208527.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

  14. XM_054352554.1 → XP_054208529.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

  15. XM_054352545.1 → XP_054208520.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

  16. XM_054352544.1 → XP_054208519.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

  17. XM_054352557.1 → XP_054208532.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  18. XM_054352558.1 → XP_054208533.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

  19. XM_054352549.1 → XP_054208524.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

  20. XM_054352546.1 → XP_054208521.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

  21. XM_054352555.1 → XP_054208530.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15021.4 GenPept UniProtKB/Swiss-Prot:O15021

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