pdgfaa platelet-derived growth factor alpha polypeptide a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdgfaaprovided by ZNC
Official Full Name: platelet-derived growth factor alpha polypeptide aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030918-2
See related: Ensembl:ENSDARG00000109371 Ensembl:ENSDARG00000110069 AllianceGenome:ZFIN:ZDB-GENE-030918-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pdgfa; pdgfa-2; zgc:100777
Summary: Predicted to enable platelet-derived growth factor receptor binding activity. Acts upstream of or within with a positive effect on neural crest cell migration. Acts upstream of or within cardiac muscle progenitor cell migration to the midline involved in heart field formation. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including anterior neural keel; chordo neural hinge; diencephalon; endoderm; and head. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (25991128..26005920, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (25971231..25986023, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish pdgf-a mRNA was present at high levels in fertilized eggs as well as in all embryonic cells up to the end of gastrulation
Title: Platelet-derived growth factor A (pdgf-a) expression during zebrafish embryonic development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle progenitor cell migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet-derived growth factor alpha polypeptide a

Names: platelet-derived growth factor alpha a; platelet-derived growth factor subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194426.3 → NP_919407.2 platelet-derived growth factor alpha polypeptide a precursor

See identical proteins and their annotated locations for NP_919407.2

Status: VALIDATED

Source sequence(s)

BX072555

UniProtKB/TrEMBL

A0A8M1P901, A5PMP7

Related

ENSDARP00000095859.4, ENSDART00000105088.7

Conserved Domains (2) summary

pfam00341
Location:95 → 178

PDGF; PDGF/VEGF domain

pfam04692
Location:21 → 94

PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

25991128..26005920 complement

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GenBank, FASTA, Sequence Viewer (Graphics)
NC_007133.7 Reference GRCz11 Primary Assembly

Range

26085338..26100299 complement

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GenBank, FASTA, Sequence Viewer (Graphics)