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Ccdc33 coiled-coil domain containing 33 [ Mus musculus (house mouse) ]

Gene ID: 382077, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc33provided by MGI
Official Full Name
coiled-coil domain containing 33provided by MGI
Primary source
MGI:MGI:1922464
See related
Ensembl:ENSMUSG00000037716 AllianceGenome:MGI:1922464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tzip1; Gm1117; 4930535E21Rik
Summary
Located in peroxisome. Is expressed in Harderian gland; brain; male reproductive gland or organ; and tongue. Orthologous to human CCDC33 (coiled-coil domain containing 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 23.9) and ovary adult (RPKM 2.7) See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 31.63 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57935956..58026111, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58028673..58118823, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57804760-57804959 Neighboring gene sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Neighboring gene STARR-positive B cell enhancer ABC_E8291 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57816329-57816438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57819923-57820197 Neighboring gene STARR-seq mESC enhancer starr_24252 Neighboring gene STARR-positive B cell enhancer ABC_E2890 Neighboring gene STARR-seq mESC enhancer starr_24253 Neighboring gene Cyp11a1 promoter region Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene predicted gene 16130 Neighboring gene stimulated by retinoic acid gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene predicted gene, 39344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein. Kaczmarek K, et al. Cytogenet Genome Res, 2009. PMID 20068295
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Ccdc33 encodes a putative peroxisomal protein and is predominantly expressed in male germ cells.
    Title: Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 33
Names
speriolin-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166282.2 → NP_001159754.1  coiled-coil domain-containing protein 33 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC158996
    Consensus CDS
    CCDS52811.1
    UniProtKB/Swiss-Prot
    Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
    UniProtKB/TrEMBL
    E9QQ55
    Related
    ENSMUSP00000096279.4, ENSMUST00000098682.10
    Conserved Domains (1) summary
    cd00030
    Location:282 → 364
    C2; C2 domain

  2. NM_001311085.2 → NP_001298014.1  coiled-coil domain-containing protein 33 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences compared to variant 1. These differences result in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC158996
    Consensus CDS
    CCDS81006.1
    UniProtKB/TrEMBL
    D3YU68
    Related
    ENSMUSP00000112613.2, ENSMUST00000119665.2
    Conserved Domains (3) summary
    cd00030
    Location:37 → 119
    C2; C2 domain
    cd16269
    Location:495 → 506
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:407 → 507
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_029212.4 → NP_083488.1  coiled-coil domain-containing protein 33 isoform 2

    See identical proteins and their annotated locations for NP_083488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC158996
    Consensus CDS
    CCDS40654.1
    UniProtKB/TrEMBL
    A0A0R4J0H2
    Related
    ENSMUSP00000040899.7, ENSMUST00000042205.13
    Conserved Domains (1) summary
    cd00030
    Location:37 → 119
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57935956..58026111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313444.1 → XP_017168933.1  coiled-coil domain-containing protein 33 isoform X2

    UniProtKB/Swiss-Prot
    Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
    Conserved Domains (2) summary
    cd00030
    Location:282 → 364
    C2; C2 domain
    TIGR02169
    Location:648 → 831
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_017313445.1 → XP_017168934.1  coiled-coil domain-containing protein 33 isoform X3

    UniProtKB/Swiss-Prot
    Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
    Conserved Domains (2) summary
    cd00030
    Location:283 → 365
    C2; C2 domain
    TIGR02169
    Location:649 → 831
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_017313447.1 → XP_017168936.1  coiled-coil domain-containing protein 33 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SR74
    Conserved Domains (2) summary
    cd00030
    Location:283 → 365
    C2; C2 domain
    TIGR02169
    Location:649 → 832
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  4. XM_017313446.1 → XP_017168935.1  coiled-coil domain-containing protein 33 isoform X4

    UniProtKB/TrEMBL
    A0A1L1SR74
    Conserved Domains (2) summary
    cd00030
    Location:283 → 365
    C2; C2 domain
    TIGR02169
    Location:649 → 832
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  5. XM_006511252.1 → XP_006511315.1  coiled-coil domain-containing protein 33 isoform X1

    UniProtKB/Swiss-Prot
    Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
    Conserved Domains (2) summary
    cd00030
    Location:283 → 365
    C2; C2 domain
    TIGR02169
    Location:649 → 832
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  6. XM_006511257.4 → XP_006511320.1  coiled-coil domain-containing protein 33 isoform X7

    Conserved Domains (1) summary
    TIGR02169
    Location:236 → 419
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  7. XM_006511254.4 → XP_006511317.1  coiled-coil domain-containing protein 33 isoform X6

    Conserved Domains (2) summary
    cd00030
    Location:37 → 119
    C2; C2 domain
    TIGR02169
    Location:403 → 586
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  8. XM_006511258.2 → XP_006511321.2  coiled-coil domain-containing protein 33 isoform X8

    Conserved Domains (1) summary
    TIGR02169
    Location:24 → 195
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  9. XM_006511259.2 → XP_006511322.2  coiled-coil domain-containing protein 33 isoform X9

    Conserved Domains (1) summary
    TIGR02169
    Location:24 → 195
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ULW6.2 GenPept UniProtKB/Swiss-Prot:Q3ULW6

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