cyp4t8 cytochrome P450, family 4, subfamily T, polypeptide 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp4t8provided by ZNC
Official Full Name: cytochrome P450, family 4, subfamily T, polypeptide 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-031219-3
See related: Ensembl:ENSDARG00000004964 AllianceGenome:ZFIN:ZDB-GENE-031219-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp4; cb1041
Summary: Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in myotome; nervous system; otic vesicle; pharyngeal arch 3-7 skeleton; and somite. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4B1 (cytochrome P450 family 4 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (4591316..4640600, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (4762027..4811305, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd24f08.y1 (e-PCR)
- UniSTS:195342

fb67e05.y1 (e-PCR)
- UniSTS:190958

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4T8; cytochrome P450, family 4, subfamily T, polypeptide 8

Names: cyp4a10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199216.2 → NP_954686.2 cytochrome P450 4T8

Status: VALIDATED

Source sequence(s)

BX927222

UniProtKB/TrEMBL

A0A8M2B477, E7FB64, Q6PH32

Related

ENSDARP00000122081.1, ENSDART00000131949.2

Conserved Domains (1) summary

pfam00067
Location:46 → 501

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

4591316..4640600 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157851.4 → XP_005157908.1 cytochrome P450, family 4, subfamily T, polypeptide 8 isoform X1

UniProtKB/TrEMBL

E7FB64

Related

ENSDARP00000071423.5, ENSDART00000076955.7

Conserved Domains (1) summary

pfam00067
Location:46 → 501

p450; Cytochrome P450