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PF3D7_0607300 uroporphyrinogen III decarboxylase [ Plasmodium falciparum 3D7 ]

Gene ID: 3885902, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0607300
Gene description
uroporphyrinogen III decarboxylase
Locus tag
PF3D7_0607300
Gene type
protein coding
RNA name
uroporphyrinogen III decarboxylase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 6
Exon count:
2
Sequence:
Chromosome: 6; NC_004327.3 (304638..306042)

Chromosome 6 - NC_004327.3Genomic Context describing neighboring genes Neighboring gene MYND-type zinc finger protein, putative Neighboring gene RING zinc finger protein, putative Neighboring gene G-protein associated signal transduction protein, putative Neighboring gene 4-hydroxybenzoate polyprenyltransferase, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004327.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localisation of Plasmodium falciparum uroporphyrinogen III decarboxylase of the heme-biosynthetic pathway in the apicoplast and characterisation of its catalytic properties. Nagaraj VA, et al. Int J Parasitol, 2009 Apr. PMID 19041871
  2. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article
  3. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uroporphyrinogen III decarboxylase
XP_966063.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004327.3 Reference assembly

    Range
    304638..306042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_960970.1 → XP_966063.1  uroporphyrinogen III decarboxylase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_966063.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V9Z4, A0A024WC53, A0A024WTQ3, A0A024XCJ6, A0A0L1I836, A0A0L7KAG5, A0A0L7LWK9, A8CBI1, C6KSS1, W4IMD4, W4IVA2, W7FGZ9, W7GAC8, W7JG66, W7K8B4
    Conserved Domains (1) summary
    cd00717
    Location:82 → 409
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...
Nucleotide Protein
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