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PF3D7_0603300 dihydroorotate dehydrogenase [ Plasmodium falciparum 3D7 ]

Gene ID: 3885966, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0603300
Gene description
dihydroorotate dehydrogenase
Locus tag
PF3D7_0603300
Gene type
protein coding
RNA name
dihydroorotate dehydrogenase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_004327.3 (130329..132038, complement)

Chromosome 6 - NC_004327.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein, putative Neighboring gene mitochondrial chaperone BCS1, putative Neighboring gene trophozoite exported protein 1 Neighboring gene cation/H+ antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004327.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria. Kokkonda S, et al. J Med Chem, 2020 May 14. PMID 32248693, Free PMC Article
  2. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. Maetani M, et al. ACS Med Chem Lett, 2017 Apr 13. PMID 28435533, Free PMC Article
  3. Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum. Dickerman BK, et al. Sci Rep, 2016 Nov 22. PMID 27874068, Free PMC Article
  4. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Deng X, et al. Acta Crystallogr F Struct Biol Commun, 2015 May. PMID 25945708, Free PMC Article
  5. In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth. Ross LS, et al. J Biol Chem, 2014 Jun 27. PMID 24782313, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The X-ray structure of Plasmodium falciparum DHODH is described at 2.3 A resolution.
    Title: The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.
  2. Point mutations in dihydroorotate dehydrogenase inhibited the growth.
    Title: In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.
  3. Results indicate that dihydroorotate dehydrogenase (PfDHODH) is an effective target for antimalarial chemotherapy.
    Title: Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.
  4. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
    Title: Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
  5. Studies will directly impact efforts to exploit PfDHODH for the development of anti-malarial chemotherapy.
    Title: Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
  6. Flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.
    Title: Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.
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Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
dihydroorotate dehydrogenase
XP_966023.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004327.3 Reference assembly

    Range
    130329..132038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_960930.1 → XP_966023.1  dihydroorotate dehydrogenase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_966023.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q08210, Q6LFN3
    UniProtKB/TrEMBL
    A0A024VAF4, A0A024VGF1, A0A024WC84, A0A024WV16, A0A024XDA6, A0A0L1I668, A0A0L7K971, A0A0L7M6L3, Q54A96, W4IKB5, W4ITK1, W7FJB2, W7G248, W7JSA8, W7K880
    Conserved Domains (1) summary
    cd04738
    Location:173 → 546
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08210.1

Gene LinkOut

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