Mcad Medium-chain acyl-CoA dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcadprovided by FlyBase
Official Full Name: Medium-chain acyl-CoA dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035811
Locus tag: Dmel_CG12262
See related: AllianceGenome:FB:FBgn0035811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ACAD; CG 12262; CG12262; Dmel\CG12262; mcad; MCAD
Summary: Enables medium-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including circulatory system; epithelium; gastrula embryo; gut section; and yolk nucleus. Used to study medium chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7719350..7721472)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7712450..7714572)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

Names: CG12262-PA; Mcad-PA; acyl-CoA dehdrogenase; medium chain acyl-CoA dehydrogenase; medium-chain acyl-coenzyme A dehydrogenase; probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial

NP_648149.1

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The following sections contain reference sequences that belong to a specific genome build. Explain