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C1QTNF8 C1q and TNF related 8 [ Homo sapiens (human) ]

Gene ID: 390664, updated on 5-Mar-2024

Summary

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Official Symbol
C1QTNF8provided by HGNC
Official Full Name
C1q and TNF related 8provided by HGNC
Primary source
HGNC:HGNC:31374
See related
Ensembl:ENSG00000184471 MIM:614147; AllianceGenome:HGNC:31374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP8; UNQ5829
Summary
Involved in positive regulation of cell motility. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See C1QTNF8 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1088226..1096306, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1099983..1108623, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1138226..1146244, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1038856-1039356 Neighboring gene SRY-box transcription factor 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1051902-1052558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1059983-1060602 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1064356-1064557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1074897-1075411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1075412-1075925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1087280-1087789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1097469-1098084 Neighboring gene Sharpr-MPRA regulatory region 13654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1113181-1113680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1119782-1120538 Neighboring gene SSTR5 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1121507-1122248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1128485-1129149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1132931-1133783 Neighboring gene somatostatin receptor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6964 Neighboring gene uncharacterized LOC107984906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1157970-1158488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1167285-1167853 Neighboring gene 16p subtelomeric meiotic recombination hotspot Neighboring gene uncharacterized LOC105371042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment. Krishnan SN, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36921737
  2. C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma. Thanasupawat T, et al. Mol Oncol, 2018 Sep. PMID 29949238, Free PMC Article
  3. C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. Glogowska A, et al. J Pathol, 2013 Dec. PMID 24014093
  4. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. Peterson JM, et al. Biochem Biophys Res Commun, 2009 Oct 16. PMID 19666007
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment.
    Title: Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment.
  2. This study demonstrates a novel role for CTRP8 in protecting human glioblastoma cells against the DNA alkylating damage of temozolomide, the standard chemotherapy drug used to treat glioblastoma. This DNA protective role of CTRP8 required a functional RXFP1-STAT3 signaling cascade in glioblastoma cells. CTRP8-RXFP1-STAT3 axis is an emerging new drug target for improved treatment of human glioblastoma.
    Title: C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.
  3. direct interaction of human CTRP8 with RXFP1
    Title: C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells.
  4. two novel human C1q/TNF family members, designated as CTRP8 and CTRP9B were described.
    Title: CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 8
Names
C1q and tumor necrosis factor related protein 8
C1q/TNF-related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207419.3 → NP_997302.2  complement C1q tumor necrosis factor-related protein 8 precursor

    See identical proteins and their annotated locations for NP_997302.2

    Status: VALIDATED

    Source sequence(s)
    AC009041, AL031713
    Consensus CDS
    CCDS32358.1
    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5
    Related
    ENSP00000330426.5, ENST00000328449.6
    Conserved Domains (2) summary
    pfam01391
    Location:69 → 111
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:118 → 246
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1088226..1096306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434100.1 → XP_047290056.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

  2. XM_047434099.1 → XP_047290055.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

  3. XM_047434101.1 → XP_047290057.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

RNA

  1. XR_001751901.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1099983..1108623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380315.1 → XP_054236290.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

  2. XM_054380317.1 → XP_054236292.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

  3. XM_054380316.1 → XP_054236291.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5

RNA

  1. XR_008489089.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60827.2 GenPept UniProtKB/Swiss-Prot:P60827

Gene LinkOut

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