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eps8a EGFR pathway substrate 8a, signaling adaptor [ Danio rerio (zebrafish) ]

Gene ID: 393212, updated on 27-Mar-2024

Summary

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Official Symbol
eps8aprovided by ZNC
Official Full Name
EGFR pathway substrate 8a, signaling adaptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-871
See related
Ensembl:ENSDARG00000102128 AllianceGenome:ZFIN:ZDB-GENE-040426-871
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eps8; zgc:56041
Summary
Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin filament bundle assembly and barbed-end actin filament capping. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See eps8a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (151505..178510, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (90899..117908)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene TANK-binding kinase 1 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene protein tyrosine phosphatase receptor type O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC56041

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor kinase substrate 8a
Names
epidermal growth factor receptor pathway substrate 8
epidermal growth factor receptor pathway substrate 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200242.1 → NP_956536.1  epidermal growth factor receptor kinase substrate 8a

    See identical proteins and their annotated locations for NP_956536.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047814
    UniProtKB/TrEMBL
    Q7ZUV6
    Conserved Domains (3) summary
    cd09540
    Location:702 → 766
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    151505..178510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299923.3 → XP_009298198.1  epidermal growth factor receptor kinase substrate 8 isoform X13

    See identical proteins and their annotated locations for XP_009298198.1

    UniProtKB/TrEMBL
    A0A8M3B1E6
    Conserved Domains (3) summary
    cd09540
    Location:755 → 819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514 → 566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_021474970.1 → XP_021330645.1  epidermal growth factor receptor kinase substrate 8 isoform X13

    UniProtKB/TrEMBL
    A0A8M3B1E6
    Conserved Domains (3) summary
    cd09540
    Location:755 → 819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514 → 566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_017354976.2 → XP_017210465.1  epidermal growth factor receptor kinase substrate 8 isoform X10

    UniProtKB/TrEMBL
    A0A8M6YXX0

  4. XM_017354975.2 → XP_017210464.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z5A1

  5. XM_009299921.2 → XP_009298196.1  epidermal growth factor receptor kinase substrate 8 isoform X11

    UniProtKB/TrEMBL
    A0A8M3ARA8
    Conserved Domains (3) summary
    cd09540
    Location:717 → 781
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:496 → 548
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_009299919.3 → XP_009298194.1  epidermal growth factor receptor kinase substrate 8 isoform X8

    UniProtKB/TrEMBL
    A0A8M3AR20
    Conserved Domains (3) summary
    cd09540
    Location:737 → 801
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:496 → 548
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_009299918.3 → XP_009298193.1  epidermal growth factor receptor kinase substrate 8 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AYF5
    Conserved Domains (3) summary
    cd09540
    Location:749 → 813
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  8. XM_009299917.2 → XP_009298192.1  epidermal growth factor receptor kinase substrate 8 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B1E2
    Conserved Domains (3) summary
    cd09540
    Location:750 → 814
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  9. XM_009299916.3 → XP_009298191.1  epidermal growth factor receptor kinase substrate 8 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ARA4
    Conserved Domains (3) summary
    cd09540
    Location:762 → 826
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  10. XM_009299914.3 → XP_009298189.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AR15
    Conserved Domains (3) summary
    cd09540
    Location:769 → 833
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  11. XM_009299915.2 → XP_009298190.1  epidermal growth factor receptor kinase substrate 8 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B8N1
    Conserved Domains (3) summary
    cd09540
    Location:770 → 834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  12. XM_009299913.3 → XP_009298188.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AYF2
    Conserved Domains (3) summary
    cd09540
    Location:770 → 834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  13. XM_005168496.3 → XP_005168553.1  epidermal growth factor receptor kinase substrate 8 isoform X14

    UniProtKB/TrEMBL
    A0A0R4IID9, A0A0R4IIJ9, A0A8M2BFT5, F1QMN2
    Related
    ENSDARP00000133193.2, ENSDART00000171333.2
    Conserved Domains (3) summary
    cd09540
    Location:702 → 766
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481 → 533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  14. XM_009299922.3 → XP_009298197.1  epidermal growth factor receptor kinase substrate 8 isoform X12

    See identical proteins and their annotated locations for XP_009298197.1

    UniProtKB/TrEMBL
    A0A8M3B1E6
    Conserved Domains (3) summary
    cd09540
    Location:755 → 819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514 → 566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  15. XM_009299920.3 → XP_009298195.1  epidermal growth factor receptor kinase substrate 8 isoform X9

    UniProtKB/TrEMBL
    A0A8M3B8N5
    Conserved Domains (3) summary
    cd09540
    Location:770 → 834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529 → 581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63 → 193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
Heading Accession and Version

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