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pdcd2 programmed cell death 2 [ Danio rerio (zebrafish) ]

Gene ID: 393370, updated on 27-Mar-2024

Summary

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Official Symbol
pdcd2provided by ZNC
Official Full Name
programmed cell death 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1236
See related
Ensembl:ENSDARG00000007892 AllianceGenome:ZFIN:ZDB-GENE-040426-1236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63685
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within erythrocyte differentiation; hematopoietic stem cell differentiation; and regulation of mitotic nuclear division. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including common myeloid progenitor; digestive system; gill; heart; and hematopoietic system. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24380132..24383805)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24249682..24253355)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene si:ch211-202m22.1 Neighboring gene ras homolog family member Ua Neighboring gene TATA box binding protein Neighboring gene zgc:153169 Neighboring gene RAB1A, member RAS oncogene family b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates. Trachtulec Z, et al. Gene, 2004 Jun 23. PMID 15194198
  2. PDCD2 controls hematopoietic stem cell differentiation during development. Kramer J, et al. Stem Cells Dev, 2013 Jan 1. PMID 22800338, Free PMC Article
  3. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC63685

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
programmed cell death protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045138.1 → NP_001038603.1  programmed cell death protein 2

    Status: PROVISIONAL

    Source sequence(s)
    AL772388
    UniProtKB/TrEMBL
    A0A8M1NA20, Q1MTH6
    Related
    ENSDARP00000017163.6, ENSDART00000022682.7
    Conserved Domains (2) summary
    pfam01753
    Location:145 → 182
    zf-MYND; MYND finger
    pfam04194
    Location:238 → 351
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    24380132..24383805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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