Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt1a9provided by MGI
Official Full Name: UDP glucuronosyltransferase 1 family, polypeptide A9provided by MGI
Primary source: MGI:MGI:3576092
See related: Ensembl:ENSMUSG00000090175 AllianceGenome:MGI:3576092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UDPGT; UGTP4; UGT1.9; UGT1-09; Ugt1a12; mUGTBr/P; UDPGT 1-9
Summary: Predicted to enable several functions, including fatty acid binding activity; protein dimerization activity; and protein kinase C binding activity. Predicted to be involved in flavonoid glucuronidation and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 233.5), liver adult (RPKM 172.5) and 9 other tissues See more
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Genomic context

Location:: 1 D; 1 44.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87998501..88147724)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88070779..88220002)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian Clock Component Rev-erbalpha Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
Title: Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
Diabetes mellitus caused a decrease in the activity of Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an increase in the activity of UGT1a9-mediated propofol O-glucuronidation in db/db mice
Title: Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 1A9

Names: UDP glycosyltransferase 1 family polypeptide A12; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-9

NP_964006.2

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201644.2 → NP_964006.2 UDP-glucuronosyltransferase 1A9 precursor

See identical proteins and their annotated locations for NP_964006.2

Status: VALIDATED

Source sequence(s)

AC087780, AC087801, AY227200

Consensus CDS

CCDS15138.1

UniProtKB/Swiss-Prot

A6H6W3, E9QN27, Q62452, Q6XL44

UniProtKB/TrEMBL

Q5FW80

Related

ENSMUSP00000073444.5, ENSMUST00000073772.5

Conserved Domains (2) summary

PHA03392
Location:9 → 500

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:24 → 519

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase