ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Gallus gallus (chicken)] - Gene

Summary

Symbol: ATICprovided by CGNC
Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by CGNC
Primary source: CGNC:2606
See related: Ensembl:ENSGALG00010011965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PURH
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (4420901..4438886)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (4362229..4380203)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bifunctional purine biosynthesis protein ATIC

Names: 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase, ATIC; AICAR transformylase/inosine monophosphate cyclohydrolase; aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase; aminoimidazole-4-carboxamide ribonucleotidetransformylase/IMP cyclohydrolase; bifunctional purine biosynthesis protein PURH

NP_001383476.1

EC 2.1.2.3

EC 3.5.4.10

NP_990509.2

EC 2.1.2.3

EC 3.5.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396547.1 → NP_001383476.1 bifunctional purine biosynthesis protein ATIC isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000235

UniProtKB/Swiss-Prot

P31335

UniProtKB/TrEMBL

B0FLP0, Q5XKY5

Conserved Domains (1) summary

COG0138
Location:8 → 562

PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
NM_205178.2 → NP_990509.2 bifunctional purine biosynthesis protein ATIC isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000235

UniProtKB/Swiss-Prot

P31335

UniProtKB/TrEMBL

B0FLP0, Q5U784, Q5XKY5

Related

ENSGALP00010016456.1, ENSGALT00010028641.1

Conserved Domains (2) summary

PRK07106
Location:204 → 593

PRK07106; phosphoribosylaminoimidazolecarboxamide formyltransferase

cd01421
Location:6 → 194

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...