NR1D2 nuclear receptor subfamily 1 group D member 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NR1D2provided by CGNC
Full Name: nuclear receptor subfamily 1 group D member 2provided by CGNC
Primary source: CGNC:49661
See related: Ensembl:ENSGALG00010001528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: REV-ERBB
Summary: This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (37109303..37137142)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (37160310..37188175)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Rev-erb alpha and beta contain a functional nuclear location signal in the DNA-binding domain, and suggest that they control their intracellular localization via a mechanism different from that of other nuclear receptors
Title: A specific and unusual nuclear localization signal in the DNA binding domain of the Rev-erb orphan receptors.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nuclear receptor subfamily 1 group D member 2

Names: Rev-erb-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205205.3 → NP_990536.2 nuclear receptor subfamily 1 group D member 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000037

UniProtKB/TrEMBL

A0A8V0XBR1

Related

ENSGALP00010001975.1, ENSGALT00010003533.1

Conserved Domains (2) summary

cd06940
Location:398 → 585

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:111 → 199

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

37109303..37137142

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015281306.4 → XP_015136792.1 nuclear receptor subfamily 1 group D member 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XBR1

Conserved Domains (2) summary

cd06940
Location:383 → 570

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:96 → 184

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
XM_040676403.2 → XP_040532337.1 nuclear receptor subfamily 1 group D member 2 isoform X2

UniProtKB/TrEMBL

A0A1D5PKA2, A0A8V0X913, F1NFX1, Q90970

Related

ENSGALP00010001974.1, ENSGALT00010003532.1

Conserved Domains (2) summary

cd06940
Location:328 → 515

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:41 → 129

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

37160310..37188175

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046910427.1 → XP_046766383.1 nuclear receptor subfamily 1 group D member 2 isoform X1
XM_046910428.1 → XP_046766384.1 nuclear receptor subfamily 1 group D member 2 isoform X2

UniProtKB/TrEMBL

A0A8V0X913