s1pr4 sphingosine-1-phosphate receptor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: s1pr4provided by ZNC
Official Full Name: sphingosine-1-phosphate receptor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-8
See related: Ensembl:ENSDARG00000074851 AllianceGenome:ZFIN:ZDB-GENE-050506-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: edg6; im:6805837; si:ch211-35n24.1
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; eye; heart; intestine; and kidney. Orthologous to human S1PR4 (sphingosine-1-phosphate receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (5320681..5323484, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (4936306..4939109, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 4

Names: endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001118891.1 → NP_001112363.1 sphingosine 1-phosphate receptor 4

Status: PROVISIONAL

Source sequence(s)

CU855875

UniProtKB/TrEMBL

A0A8N1YZH4, F1QC10

Related

ENSDARP00000112534.1, ENSDART00000145785.2

Conserved Domains (2) summary

pfam00001
Location:62 → 305

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 250

7tm_4; Olfactory receptor