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APP amyloid beta precursor protein [ Canis lupus familiaris (dog) ]

Gene ID: 403407, updated on 3-Apr-2024

Summary

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Official Symbol
APPprovided by VGNC
Official Full Name
amyloid beta precursor proteinprovided by VGNC
Primary source
VGNC:VGNC:38010
See related
Ensembl:ENSCAFG00845015660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ABPP
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 31
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (21405966..21669000, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (21345590..21608332, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (21899466..22164885, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (21422808..21685736, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (21425054..21689657, complement)

Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093558 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102151217 Neighboring gene uncharacterized LOC111093497 Neighboring gene U6 spliceosomal RNA Neighboring gene cysteine and tyrosine rich 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs. Panek WK, et al. Mol Neurobiol, 2021 Feb. PMID 32970242, Free PMC Article
  2. Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. González-Martínez Á, et al. Exp Gerontol, 2011 Jul. PMID 21377518
  3. Copper promotes the trafficking of the amyloid precursor protein. Acevedo KM, et al. J Biol Chem, 2011 Mar 11. PMID 21177866, Free PMC Article
  4. Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits. Pugliese M, et al. Acta Neuropathol, 2006 Aug. PMID 16775693
  5. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Johnstone EM, et al. Brain Res Mol Brain Res, 1991 Jul. PMID 1656157

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs.
    Title: Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs.
  2. increased plasma Abeta1-42 levels and Abeta42/40 ratio could be a biomarker for canine cognitive dysfunction
    Title: Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease.
  3. Copper promotes the trafficking of the amyloid precursor protein.
    Title: Copper promotes the trafficking of the amyloid precursor protein.
  4. results in dog suggest that Abeta diffuse plaque formation and tau hyperphosphorylation are independent events, both occurring during the process of aging
    Title: Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-beta precursor protein; amyloid-beta A4 protein
Names
alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
amyloid precursor protein
amyloid-beta (A4) precursor protein
beta-amyloid precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006601.2 → NP_001006601.2  amyloid-beta precursor protein isoform APP-770 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (APP-770).
    Source sequence(s)
    AY498706, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    A0A8C0LP07, A0A8C0NP81, A0A8C0TFV8, A0A8I3P9H6, Q56JK6, Q6RH30
    Related
    ENSCAFP00845023583.1, ENSCAFT00845030063.1
    Conserved Domains (5) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:675 → 713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716 → 766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366 → 548
    APP_E2; E2 domain of amyloid precursor protein

  2. NM_001293275.1 → NP_001280204.1  amyloid-beta precursor protein isoform APP-751 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform APP-751, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498708, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    A0A8C0Z3X8, A0A8I3RZM5, Q6RH28
    Related
    ENSCAFP00845023694.1, ENSCAFT00845030217.1
    Conserved Domains (5) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:656 → 694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697 → 747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein

  3. NM_001293276.1 → NP_001280205.1  amyloid-beta precursor protein isoform APP-714 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform APP-714, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498706, AY498708, AY926579, AY926581, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    A0A8C0TG24, A0A8I3S2G8, Q56JK4
    Related
    ENSCAFP00845023754.1, ENSCAFT00845030292.1
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:619 → 657
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:660 → 710
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:310 → 492
    APP_E2; E2 domain of amyloid precursor protein

  4. NM_001293279.1 → NP_001280208.1  amyloid-beta precursor protein isoform APP-695 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform APP-695, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AY498707, AY926579, CO680263, DN394364, DN877827
    UniProtKB/TrEMBL
    A0A8C0LRE1, A0A8C0TGH9, A0A8I3S2H9, Q6RH29
    Related
    ENSCAFP00845023839.1, ENSCAFT00845030397.1
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:600 → 638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:641 → 691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:291 → 473
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051835.1 Reference ROS_Cfam_1.0

    Range
    21405966..21669000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443100.1 → XP_038299028.1  amyloid-beta A4 protein isoform X3

    UniProtKB/TrEMBL
    Q6RH29
    Conserved Domains (3) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291 → 473
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:600 → 674
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  2. XM_038443099.1 → XP_038299027.1  amyloid-beta A4 protein isoform X2

    UniProtKB/TrEMBL
    Q6RH28
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:347 → 529
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:656 → 730
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  3. XM_038443098.1 → XP_038299026.1  amyloid-beta A4 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSA4, A0A8C0NP81, A0A8C0TFK8, A0A8I3S2F2, Q56JK6, Q6RH30
    Related
    ENSCAFP00845023645.1, ENSCAFT00845030144.1
    Conserved Domains (4) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294 → 342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:366 → 548
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:675 → 749
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049291.1 Alternate UMICH_Zoey_3.1

    Range
    21422808..21685736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

    Range
    21425054..21689657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

    Range
    21899466..22164885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21345590..21608332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28280.1 GenPept UniProtKB/Swiss-Prot:Q28280

Gene LinkOut

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