EGF epidermal growth factor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: EGFprovided by VGNC
Official Full Name: epidermal growth factorprovided by VGNC
Primary source: VGNC:VGNC:40235
See related: Ensembl:ENSCAFG00845030111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CEGF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	32	NC_051836.1 (30294579..30388079)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	32	NC_006614.4 (11863120..11956432, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	32	NC_049253.1 (9723676..9817337, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	32	NC_049292.1 (30288558..30381524)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	32	NC_049773.1 (30031820..30125429)

Chromosome 32 - NC_051836.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells
Title: FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells.
epidermal growth factor, transforming growth factor-alpha and EGF receptor may be involved in testicular maturation and function in the dog
Title: Expression and localization of epidermal growth factor, transforming growth factor-α and epidermal growth factor receptor in the canine testis.
Matrix stiffening significantly sensitizes cells to EGF and enables the loss of contact inhibition.
Title: Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation.
In malignant tumours (non-IMC and IMC), a strong correlation was observed between EGF and: progesterone, 17beta-estradiol, androstenedione, and dehydroepiandrosterone
Title: Positive correlation of steroid hormones and EGF in canine mammary cancer.
EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly
Title: Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells.

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General gene information

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Markers

EGF (e-PCR), detects polymorphism
- UniSTS:266098

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pro-epidermal growth factor

Names: epidermal growth factor (beta-urogastrone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003094.3 → NP_001003094.3 pro-epidermal growth factor precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000366

UniProtKB/TrEMBL

A0A8C0P5J0, A0A8I3Q5L9, A0A8P0SGL1

Related

ENSCAFP00845041962.1, ENSCAFT00845053413.1

Conserved Domains (7) summary

PHA02887
Location:975 → 1015

PHA02887; EGF-like protein; Provisional

smart00135
Location:637 → 678

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:873 → 913

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:915 → 943

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam12662
Location:338 → 361

cEGF; Complement Clr-like EGF-like

pfam14670
Location:747 → 782

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:353 → 395

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051836.1 Reference ROS_Cfam_1.0

Range

30294579..30388079

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038443775.1 → XP_038299703.1 pro-epidermal growth factor isoform X2

UniProtKB/TrEMBL

A0A8I3Q9R0, A0A8P0PMN8

Related

ENSCAFP00845042046.1, ENSCAFT00845053513.1

Conserved Domains (7) summary

PHA02887
Location:934 → 974

PHA02887; EGF-like protein; Provisional

smart00135
Location:637 → 678

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:832 → 872

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:874 → 902

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam12662
Location:338 → 361

cEGF; Complement Clr-like EGF-like

pfam14670
Location:747 → 782

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:353 → 395

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038443776.1 → XP_038299704.1 pro-epidermal growth factor isoform X3

UniProtKB/TrEMBL

A0A8P0SGL1

Conserved Domains (7) summary

PHA02887
Location:897 → 937

PHA02887; EGF-like protein; Provisional

smart00135
Location:559 → 600

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:795 → 835

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:837 → 865

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam12662
Location:260 → 283

cEGF; Complement Clr-like EGF-like

pfam14670
Location:669 → 704

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:275 → 317

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038443774.1 → XP_038299702.1 pro-epidermal growth factor isoform X1

UniProtKB/TrEMBL

A0A8P0SGL1

Conserved Domains (7) summary

PHA02887
Location:974 → 1014

PHA02887; EGF-like protein; Provisional

smart00135
Location:637 → 678

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:872 → 912

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:914 → 942

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam12662
Location:338 → 361

cEGF; Complement Clr-like EGF-like

pfam14670
Location:747 → 782

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:353 → 395

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038443777.1 → XP_038299705.1 pro-epidermal growth factor isoform X4

UniProtKB/TrEMBL

A0A8C0KS72

Conserved Domains (6) summary

smart00135
Location:637 → 678

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:873 → 913

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:915 → 943

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam12662
Location:338 → 361

cEGF; Complement Clr-like EGF-like

pfam14670
Location:747 → 782

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:353 → 395

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...