HTR2A 5-hydroxytryptamine receptor 2A [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HTR2Aprovided by VGNC
Official Full Name: 5-hydroxytryptamine receptor 2Aprovided by VGNC
Primary source: VGNC:VGNC:110511
See related: Ensembl:ENSCAFG00845007028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: 5-HT-2; 5-HT-2A; 5-HTR2A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	22	NC_051826.1 (4566315..4626240)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	22	NC_006604.4 (4498607..4555448)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	22	NC_049243.1 (4417008..4474072)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	22	NC_049282.1 (4348779..4405847)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	22	NC_049763.1 (4412667..4469478)

Chromosome 22 - NC_051826.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There was a positive association between gene expression of the 5-HT2BR in the mitral valve and myocardium and clinical presence of canine myxomatous mitral valve disease. The same association was not found for the 5-HT2AR.
Title: Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease.
functional existence in osteosarcoma cell line, indicating that intracellular second messenger signal coupling is different between normal and malignant cells
Title: The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
5HT2A receptor inhibition with APD791, even when initiated after the onset of recurrent thrombosis, improves coronary patency in the in vivo canine model.
Title: Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.

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General gene information

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Markers

HTR2A-2 (e-PCR)
- UniSTS:31941

HTR2A-112F (e-PCR)
- UniSTS:31941

REN42F10 (e-PCR)
- UniSTS:264695

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotransmitter receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2A

Names: 5HT2A receptor; serotonin receptor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005869.1 → NP_001005869.1 5-hydroxytryptamine receptor 2A

See identical proteins and their annotated locations for NP_001005869.1

Status: PROVISIONAL

Source sequence(s)

AB193092

UniProtKB/Swiss-Prot

O46635, Q50DZ9, Q60F96

UniProtKB/TrEMBL

A0A8C0L4N4

Related

ENSCAFP00845009749.1, ENSCAFT00845012480.1

Conserved Domains (1) summary

cd15304
Location:75 → 390

7tmA_5-HT2A; serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051826.1 Reference ROS_Cfam_1.0

Range

4566315..4626240

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038430767.1 → XP_038286695.1 5-hydroxytryptamine receptor 2A isoform X2

Conserved Domains (2) summary

cd14964
Location:27 → 50

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 227

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_038430765.1 → XP_038286693.1 5-hydroxytryptamine receptor 2A isoform X1

Conserved Domains (2) summary

cd14964
Location:22 → 52

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:12 → 264

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_038430766.1 → XP_038286694.1 5-hydroxytryptamine receptor 2A isoform X2

Conserved Domains (2) summary

cd14964
Location:27 → 50

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 227

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily