CSF2 colony stimulating factor 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CSF2provided by VGNC
Official Full Name: colony stimulating factor 2provided by VGNC
Primary source: VGNC:VGNC:39654
See related: Ensembl:ENSCAFG00845009774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GM-CSF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	11	NC_051815.1 (21128373..21132476)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	11	NC_006593.4 (19140218..19142512)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	11	NC_049232.1 (20339024..20341318)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	11	NC_049271.1 (19849460..19851754)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	11	NC_049752.1 (19697439..19699733)

Chromosome 11 - NC_051815.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983
Title: MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.
The results suggest that GM-CSF production mediated by the cysteine protease is regulated not only by NFAT but also by unknown signalling pathways in canine keratinocytes.
Title: Involvement of nuclear factor of activated T cells in granulocyte-macrophage colony-stimulating factor production in canine keratinocytes stimulated with a cysteine protease.
This study suggests that interferon-gamma may suppress granulocyte-macrophage colony stimulating factor production from canine keratinocytes, although further studies are required to confirm this.
Title: Effect of recombinant canine interferon-γ on granulocyte-macrophage colony-stimulating factor, transforming growth factor-β and CC chemokine ligand 17 mRNA transcription in a canine keratinocyte cell line (CPEK).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables granulocyte macrophage colony-stimulating factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: granulocyte-macrophage colony-stimulating factor

Names: CSF; colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003245.1 → NP_001003245.1 granulocyte-macrophage colony-stimulating factor precursor

See identical proteins and their annotated locations for NP_001003245.1

Status: PROVISIONAL

Source sequence(s)

S49738

UniProtKB/Swiss-Prot

P48749

UniProtKB/TrEMBL

A0A8I3ND87

Related

ENSCAFP00845013427.1, ENSCAFT00845017228.1

Conserved Domains (1) summary

cd00040
Location:18 → 138

CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051815.1 Reference ROS_Cfam_1.0

Range

21128373..21132476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038680906.1 → XP_038536834.1 granulocyte-macrophage colony-stimulating factor isoform X1

Conserved Domains (1) summary

cd00040
Location:18 → 138

CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...