syk spleen tyrosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sykprovided by ZNC
Official Full Name: spleen tyrosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040702-3
See related: Ensembl:ENSDARG00000008186 AllianceGenome:ZFIN:ZDB-GENE-040702-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (5533840..5591965, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (5533536..5591675, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

syk and zap-70 function redundantly in an early progenitor to promote the migration of intersegmental vessel angioblasts and lymphangioblasts that contribute to the thoracic duct, either downstream of, or in parallel to vegfa.
Title: Syk and Zap-70 function redundantly to promote angioblast migration.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell migration involved in sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase SYK

Names: spleen protein tyrosine kinase

NP_998008.2

EC 2.7.10.1

XP_005155595.1

EC 2.7.10.1

XP_005155596.1

EC 2.7.10.1

XP_021334822.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212843.2 → NP_998008.2 tyrosine-protein kinase SYK

Status: VALIDATED

Source sequence(s)

CD284981, CU466285, FP102769

UniProtKB/TrEMBL

A0A0R4IBB3, A0A8M1PIE3, E9QFU7

Related

ENSDARP00000122788.4, ENSDART00000141943.4

Conserved Domains (3) summary

cd05116
Location:325 → 581

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:8 → 111

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:159 → 260

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

5533840..5591965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155539.4 → XP_005155596.1 tyrosine-protein kinase SYK isoform X1

See identical proteins and their annotated locations for XP_005155596.1

UniProtKB/TrEMBL

A0A8M2B201, F1QFN4

Conserved Domains (4) summary

cd05116
Location:348 → 604

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:8 → 111

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:159 → 260

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

pfam07714
Location:349 → 599

Pkinase_Tyr; Protein tyrosine kinase
XM_021479147.1 → XP_021334822.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A0A0R4IBB3, A0A8M1PIE3, E9QFU7

Related

ENSDARP00000132135.1, ENSDART00000164558.2

Conserved Domains (3) summary

cd05116
Location:325 → 581

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:8 → 111

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:159 → 260

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_005155538.4 → XP_005155595.1 tyrosine-protein kinase SYK isoform X1

See identical proteins and their annotated locations for XP_005155595.1

UniProtKB/TrEMBL

A0A8M2B201, F1QFN4

Related

ENSDARP00000003321.7, ENSDART00000005292.8

Conserved Domains (4) summary

cd05116
Location:348 → 604

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:8 → 111

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:159 → 260

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

pfam07714
Location:349 → 599

Pkinase_Tyr; Protein tyrosine kinase