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got1 glutamic-oxaloacetic transaminase 1, soluble [ Danio rerio (zebrafish) ]

Gene ID: 406330, updated on 27-Mar-2024

Summary

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Official Symbol
got1provided by ZNC
Official Full Name
glutamic-oxaloacetic transaminase 1, solubleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2003
See related
Ensembl:ENSDARG00000039093 AllianceGenome:ZFIN:ZDB-GENE-040426-2003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55996; wu:fj63b09
Summary
Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to act upstream of or within biosynthetic process and cellular amino acid metabolic process. Predicted to be active in cytosol. Is expressed in retina. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See got1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (40437550..40457421)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (40311658..40331532)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene NK3 homeobox 3 Neighboring gene NK2 homeobox 3 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 1 Neighboring gene heparanase 2 Neighboring gene HPS1 biogenesis of lysosomal organelles complex 3 subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article
  2. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
  3. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Lam SH, et al. Biochim Biophys Acta, 2013 Oct. PMID 23791553
  4. Effects of postprandial starvation on mRNA expression of endocrine-, amino acid and peptide transporter-, and metabolic enzyme-related genes in zebrafish (Danio rerio). Tian J, et al. Fish Physiol Biochem, 2015 Jun. PMID 25805459
  5. Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Probst J, et al. Exp Neurol, 2020 Sep. PMID 32339612

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-aspartate:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aspartate aminotransferase, cytoplasmic
Names
aspartate aminotransferase 1
NP_998222.1
XP_017214217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213057.2 → NP_998222.1  aspartate aminotransferase, cytoplasmic

    See identical proteins and their annotated locations for NP_998222.1

    Status: VALIDATED

    Source sequence(s)
    BX005330, CU929568
    UniProtKB/TrEMBL
    A0A0R4IBN7, A9JSX1, Q7ZUW8
    Related
    ENSDARP00000129948.1, ENSDART00000167859.2
    Conserved Domains (2) summary
    PTZ00376
    Location:1 → 409
    PTZ00376; aspartate aminotransferase; Provisional
    pfam00155
    Location:29 → 402
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    40437550..40457421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358728.2 → XP_017214217.1  aspartate aminotransferase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A0R4IBN7, A9JSX1, Q7ZUW8
    Conserved Domains (2) summary
    PTZ00376
    Location:1 → 409
    PTZ00376; aspartate aminotransferase; Provisional
    pfam00155
    Location:29 → 402
    Aminotran_1_2; Aminotransferase class I and II

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394887.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    130154..137956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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