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MAP6 microtubule associated protein 6 [ Homo sapiens (human) ]

Gene ID: 4135, updated on 4-Jan-2025

Summary

Official Symbol
MAP6provided by HGNC
Official Full Name
microtubule associated protein 6provided by HGNC
Primary source
HGNC:HGNC:6868
See related
Ensembl:ENSG00000171533 MIM:601783; AllianceGenome:HGNC:6868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STOP; MTAP6; MAP6-N; N-STOP
Summary
This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.6), testis (RPKM 2.8) and 13 other tissues See more
Orthologs
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Genomic context

See MAP6 in Genome Data Viewer
Location:
11q13.5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75586918..75669038, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75516323..75598423, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75297963..75380083, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene uncharacterized LOC105369389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75236337-75236837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75242693-75243509 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4348 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:75248027-75248527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75254283-75254784 Neighboring gene VISTA enhancer hs1748 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4355 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4356 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75272978-75273517 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75273518-75274058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:75274059-75274597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75276989-75277604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75277605-75278219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75279454-75279954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:75287552-75288052 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:75289175-75289343 Neighboring gene serpin family H member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3771 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75295275-75295854 Neighboring gene MAP6 antisense RNA 1 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5274 Neighboring gene uncharacterized LOC105369392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3773 Neighboring gene monoacylglycerol O-acyltransferase 2 Neighboring gene RNA, 7SL, cytoplasmic 786, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ41346, KIAA1878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding  
enables microtubule binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton-dependent intracellular transport  
involved_in dendrite morphogenesis  
involved_in dendrite morphogenesis PubMed 
involved_in lysosome localization PubMed 
involved_in microtubule cytoskeleton organization  
involved_in positive regulation of axonogenesis  
involved_in regulation of microtubule cytoskeleton organization  
Component Evidence Code Pubs
is_active_in Golgi-associated vesicle  
is_active_in axon  
is_active_in cis-Golgi network  
is_active_in dendrite  
is_active_in microtubule  
located_in microtubule PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in transport vesicle membrane  

General protein information

Preferred Names
microtubule-associated protein 6
Names
CTD-2530H12.7
MAP-6
stable tubule-only polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052841.1 RefSeqGene

    Range
    7071..89191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033063.2NP_149052.1  microtubule-associated protein 6 isoform 1

    See identical proteins and their annotated locations for NP_149052.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AB058781, AK123340, AP001922, BC063860
    Consensus CDS
    CCDS31641.1
    UniProtKB/Swiss-Prot
    A7E2A1, Q6P3T0, Q6ZWB8, Q96JE9
    Related
    ENSP00000307093.3, ENST00000304771.8
    Conserved Domains (1) summary
    pfam05217
    Location:298406
    STOP; STOP protein
  2. NM_207577.1NP_997460.1  microtubule-associated protein 6 isoform 2

    See identical proteins and their annotated locations for NP_997460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 3' coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB058781, BC041411, BC063860
    Consensus CDS
    CCDS44686.1
    UniProtKB/Swiss-Prot
    Q96JE9
    Related
    ENSP00000415108.2, ENST00000434603.2
    Conserved Domains (1) summary
    pfam05217
    Location:298406
    STOP; STOP protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75586918..75669038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017755.3XP_016873244.1  microtubule-associated protein 6 isoform X1

  2. XM_017017756.2XP_016873245.1  microtubule-associated protein 6 isoform X2

  3. XM_017017758.2XP_016873247.1  microtubule-associated protein 6 isoform X3

    Related
    ENSP00000434278.1, ENST00000526740.3
  4. XM_006718556.5XP_006718619.1  microtubule-associated protein 6 isoform X5

    Conserved Domains (1) summary
    pfam05217
    Location:298354
    STOP; STOP protein
  5. XM_011545039.4XP_011543341.1  microtubule-associated protein 6 isoform X4

    Conserved Domains (1) summary
    pfam05217
    Location:298354
    STOP; STOP protein

RNA

  1. XR_949933.4 RNA Sequence

  2. XR_949932.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75516323..75598423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368815.1XP_054224790.1  microtubule-associated protein 6 isoform X1

  2. XM_054368816.1XP_054224791.1  microtubule-associated protein 6 isoform X2

  3. XM_054368817.1XP_054224792.1  microtubule-associated protein 6 isoform X3

  4. XM_054368819.1XP_054224794.1  microtubule-associated protein 6 isoform X5

  5. XM_054368818.1XP_054224793.1  microtubule-associated protein 6 isoform X4

RNA

  1. XR_008488398.1 RNA Sequence

  2. XR_008488397.1 RNA Sequence

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