Su(fu) Suppressor of fused [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(fu)provided by FlyBase
Official Full Name: Suppressor of fusedprovided by FlyBase
Primary source: FLYBASE:FBgn0005355
Locus tag: Dmel_CG6054
See related: AllianceGenome:FB:FBgn0005355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6054; d Sufu; Dmel\CG6054; dSufu; su(fu); Su(Fu); SU(FU); sufu; Sufu; SuFu; SUFU
Summary: Enables nuclear localization sequence binding activity and protein sequestering activity. Involved in cytoplasmic sequestering of transcription factor; negative regulation of nucleocytoplasmic transport; and negative regulation of smoothened signaling pathway. Located in cytosol and nucleus. Part of protein-containing complex. Is expressed in organism. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 87C5-87C5; 3-52 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12689873..12691468, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8515595..8517190, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
Title: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
Sufu can sequester Ci/Gli in the cytoplasm through binding to an N-terminal site while inhibiting Ci/Gli activity in the nucleus depending on a C-terminal Sufu-interacting site.
Title: Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction.
Drosophila Hedgehog signaling promotes downregulation of Su(fu) through its target protein HIB (Hh-induced BTB protein).
Title: Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.
Suppressor of fused (Sufu) opposes Trn-mediated Ci nuclear import by masking its PY-nuclear localization sequence.
Title: Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling.
The 'closed' form of Sufu is stabilized by Gli binding and inhibited by Hh treatment, whereas the 'open' state of Sufu is promoted by Gli-dissociation and Hh signaling.
Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Su(fu) causes the Rdx switch between two mchanisms of Cubitus interruptus regulation.
Title: Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk.
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.
Title: Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.
Su(fu) protein levels and isoforms are crucial for the modulation of the different Ci states that control Hh target gene expression.
Title: Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.
Differential Hh target gene regulation can be accomplished by differential sensitivity of Cos2 and Su(Fu) to Hh.
Title: Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused.
This protein, a component of the Ci signaling complex, functions to block nuclear import of Ci.
Title: Genetic dissection of the Drosophila Cubitus interruptus signaling complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic sequestering of transcription factor	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: suppressor of fused

Names: CG6054-PA; Su(fu)-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12689873..12691468 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080502.5 → NP_536750.2 suppressor of fused [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536750.2

Status: REVIEWED

UniProtKB/TrEMBL

Q27279, Q9VG38

Related

FBpp0082134

Conserved Domains (2) summary

pfam05076
Location:52 → 236

SUFU; Suppressor of fused protein (SUFU)

pfam12470
Location:250 → 450

SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain