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MEF2D myocyte enhancer factor 2D [ Homo sapiens (human) ]

Gene ID: 4209, updated on 3-Apr-2024

Summary

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Official Symbol
MEF2Dprovided by HGNC
Official Full Name
myocyte enhancer factor 2Dprovided by HGNC
Primary source
HGNC:HGNC:6997
See related
Ensembl:ENSG00000116604 MIM:600663; AllianceGenome:HGNC:6997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 18.8), brain (RPKM 15.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MEF2D in Genome Data Viewer
Location:
1q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156463727..156500775, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155602298..155639356, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156433519..156470567, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene Rh family B glycoprotein Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene MIR9-1 host gene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene microRNA 9-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene tetratricopeptide repeat domain 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The transcription factor Mef2d regulates B:T synapse-dependent GC-T(FH) differentiation and IL-21-mediated humoral immunity. Kim YJ, et al. Sci Immunol, 2023 Mar 31. PMID 36961907, Free PMC Article
  2. Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia. Zhao L, et al. Blood Adv, 2021 Nov 23. PMID 34597364, Free PMC Article
  3. Purification, crystallization, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex. Chen Z, et al. Protein Expr Purif, 2021 Mar. PMID 33221504
  4. MEF2D-rearranged acute lymphoblastic leukemia resembles Burkitt lymphoma/leukemia. Sun J, et al. Ann Hematol, 2020 Jan. PMID 31781846
  5. Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Hirano D, et al. Oncogene, 2019 Mar. PMID 30478446

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
    Title: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
  2. Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion.
    Title: Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion.
  3. A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer.
    Title: A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer.
  4. [Clinical characteristics and outcomes of childhood B-ALL with ZNF384 and MEF2D rearrangements].
    Title: [Clinical characteristics and outcomes of childhood B-ALL with ZNF384 and MEF2D rearrangements].
  5. The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity.
    Title: The transcription factor Mef2d regulates B:T synapse-dependent GC-T(FH) differentiation and IL-21-mediated humoral immunity.
  6. Dysregulation of Kruppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
    Title: Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes.
  7. KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D.
    Title: KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D.
  8. Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance.
    Title: Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance.
  9. Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.
    Title: Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.
  10. Nucleolar and spindleassociated protein 1 promotes nonsmall cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
    Title: Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686I1536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endochondral ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myocyte-specific enhancer factor 2D
Names
MADS box transcription enhancer factor 2, polypeptide D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271629.2 → NP_001258558.1  myocyte-specific enhancer factor 2D isoform 2

    See identical proteins and their annotated locations for NP_001258558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and splice site in the 5' UTR, and lacks an internal in-frame exon in the coding region, compared to variant 1. The resulting isoform (2, also known as hMEF2Da0), is shorter than isoform 1.
    Source sequence(s)
    AL139412, BC040949, R42560
    Consensus CDS
    CCDS60304.1
    UniProtKB/TrEMBL
    Q4LE66
    Related
    ENSP00000353803.3, ENST00000360595.7
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  2. NM_005920.4 → NP_005911.1  myocyte-specific enhancer factor 2D isoform 1

    See identical proteins and their annotated locations for NP_005911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as hMEF2Dab).
    Source sequence(s)
    AL139412, BC054520, DC377787, R42560
    Consensus CDS
    CCDS1143.1
    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
    UniProtKB/TrEMBL
    Q4LE66
    Related
    ENSP00000271555.5, ENST00000348159.9
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156463727..156500775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421004.1 → XP_047276960.1  myocyte-specific enhancer factor 2D isoform X2

  2. XM_047421009.1 → XP_047276965.1  myocyte-specific enhancer factor 2D isoform X3

  3. XM_005245169.5 → XP_005245226.1  myocyte-specific enhancer factor 2D isoform X1

    See identical proteins and their annotated locations for XP_005245226.1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  4. XM_006711334.4 → XP_006711397.1  myocyte-specific enhancer factor 2D isoform X4

    UniProtKB/TrEMBL
    Q4LE66
    Related
    ENSP00000476788.1, ENST00000464356.6
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  5. XM_006711332.4 → XP_006711395.1  myocyte-specific enhancer factor 2D isoform X2

    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:96 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  6. XM_006711333.3 → XP_006711396.1  myocyte-specific enhancer factor 2D isoform X3

    See identical proteins and their annotated locations for XP_006711396.1

    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  7. XM_017001315.2 → XP_016856804.1  myocyte-specific enhancer factor 2D isoform X3

    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  8. XM_006711330.4 → XP_006711393.1  myocyte-specific enhancer factor 2D isoform X1

    See identical proteins and their annotated locations for XP_006711393.1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  9. XM_047421002.1 → XP_047276958.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  10. XM_047420999.1 → XP_047276955.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  11. XM_047421005.1 → XP_047276961.1  myocyte-specific enhancer factor 2D isoform X3

  12. XM_005245170.4 → XP_005245227.1  myocyte-specific enhancer factor 2D isoform X1

    See identical proteins and their annotated locations for XP_005245227.1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  13. XM_047420994.1 → XP_047276950.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  14. XM_047420993.1 → XP_047276949.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  15. XM_047420998.1 → XP_047276954.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  16. XM_047420997.1 → XP_047276953.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  17. XM_047420995.1 → XP_047276951.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  18. XM_017001314.2 → XP_016856803.1  myocyte-specific enhancer factor 2D isoform X3

    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  19. XM_011509569.4 → XP_011507871.1  myocyte-specific enhancer factor 2D isoform X1

    See identical proteins and their annotated locations for XP_011507871.1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6
    UniProtKB/TrEMBL
    Q4LE66
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  20. XM_047421015.1 → XP_047276971.1  myocyte-specific enhancer factor 2D isoform X5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791758.1 Reference GRCh38.p14 PATCHES

    Range
    22284..59332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332846.1 → XP_054188821.1  myocyte-specific enhancer factor 2D isoform X2

  2. XM_054332851.1 → XP_054188826.1  myocyte-specific enhancer factor 2D isoform X3

  3. XM_054332841.1 → XP_054188816.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  4. XM_054332852.1 → XP_054188827.1  myocyte-specific enhancer factor 2D isoform X4

  5. XM_054332845.1 → XP_054188820.1  myocyte-specific enhancer factor 2D isoform X2

  6. XM_054332847.1 → XP_054188822.1  myocyte-specific enhancer factor 2D isoform X3

  7. XM_054332850.1 → XP_054188825.1  myocyte-specific enhancer factor 2D isoform X3

  8. XM_054332842.1 → XP_054188817.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  9. XM_054332843.1 → XP_054188818.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  10. XM_054332849.1 → XP_054188824.1  myocyte-specific enhancer factor 2D isoform X3

  11. XM_054332844.1 → XP_054188819.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  12. XM_054332848.1 → XP_054188823.1  myocyte-specific enhancer factor 2D isoform X3

  13. XM_054332853.1 → XP_054188828.1  myocyte-specific enhancer factor 2D isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155602298..155639356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336657.1 → XP_054192632.1  myocyte-specific enhancer factor 2D isoform X2

  2. XM_054336662.1 → XP_054192637.1  myocyte-specific enhancer factor 2D isoform X3

  3. XM_054336652.1 → XP_054192627.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  4. XM_054336663.1 → XP_054192638.1  myocyte-specific enhancer factor 2D isoform X4

  5. XM_054336656.1 → XP_054192631.1  myocyte-specific enhancer factor 2D isoform X2

  6. XM_054336658.1 → XP_054192633.1  myocyte-specific enhancer factor 2D isoform X3

  7. XM_054336661.1 → XP_054192636.1  myocyte-specific enhancer factor 2D isoform X3

  8. XM_054336653.1 → XP_054192628.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  9. XM_054336654.1 → XP_054192629.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  10. XM_054336660.1 → XP_054192635.1  myocyte-specific enhancer factor 2D isoform X3

  11. XM_054336655.1 → XP_054192630.1  myocyte-specific enhancer factor 2D isoform X1

    UniProtKB/Swiss-Prot
    D3DVC0, Q14814, Q14815, Q5T9U5, Q5T9U6

  12. XM_054336659.1 → XP_054192634.1  myocyte-specific enhancer factor 2D isoform X3

  13. XM_054336664.1 → XP_054192639.1  myocyte-specific enhancer factor 2D isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14814.1 GenPept UniProtKB/Swiss-Prot:Q14814

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